发表机构
Universitat de Barcelona; Institute of Complex Systems (UBICS); Max Planck Institute for the Physics of Complex Systems; Center for Systems Biology Dresden; Cluster of Excellence Physics of Life, TU Dresden; Institució Catalana de Recerca i Estudis Avançats (ICREA)（巴塞罗那大学; 复杂系统研究所; 马克斯·普朗克复杂系统物理研究所; 德累斯顿系统生物学中心; 德累斯顿工业大学生命物理学卓越集群; 加泰罗尼亚研究高级机构）
机构由 AI 辅助整理，请以论文原文为准。AI 中文总结
该研究将细胞聚集体建模为主动极性液滴，通过主动杨氏-杜普雷方程揭示了组织主动润湿转变的机制，解释了实验中常见的部分润湿状态。
AI 中文摘要
在诸多生物过程中，细胞聚集体会在基底上扩散，此过程属于主动润湿。然而，现有的组织扩散模型并未明确捕捉到部分润湿状态，即细胞聚集体达到非零接触角的状态。在此，我们将细胞聚集体建模为主动极性液滴，预测了部分润湿与完全润湿之间的转变。该转变源于组织表面张力与主动牵引力的竞争，这一竞争可通过主动杨氏-杜普雷方程（active Young-Dupré equation）来描述。主动润湿转变是不连续的，且存在一个参数区域，在此区域内部分润湿和完全润湿均可能发生。与被动润湿不同，该转变取决于组织黏度、基底摩擦等动力学参数。最后，加入收缩性细胞间主动应力会导致接触角增大，甚至出现完全去润湿。总体而言，我们的工作预测了组织的主动润湿转变，并捕捉到了实验中常观测到的部分润湿状态。
英文摘要
During many biological processes, cell aggregates spread on substrates in a process of active wetting. The existing models of tissue spreading, however, do not explicitly capture the state of partial wetting, in which the cell aggregate reaches a non-zero contact angle. Here, modeling cell aggregates as active polar liquid droplets, we predict a transition between partial and complete wetting. This transition emerges from the competition between tissue surface tension and active traction forces, which is captured in an active Young-Dupré equation. The active wetting transition is discontinuous, and it features a region of parameters in which both partial and complete wetting are possible. Unlike in passive wetting, the transition depends on dynamical parameters such as the tissue viscosity and substrate friction. Finally, adding contractile intercellular active stresses leads to higher contact angles and even full dewetting. Overall, our work predicts an active wetting transition for tissues and it captures the partial wetting states often seen in experiments.
