AI 中文总结
本研究在荷兰、爱尔兰队列验证ALS相关β振荡变化，发现爱尔兰队列ALS患者βERD和ERS降低，荷兰队列未重复，该指标或可作为ALS运动衰退的EEG标记物。
AI 中文摘要
监测肌萎缩侧索硬化（ALS）患者运动与认知功能障碍的可重复生物标志物是亟需的。既往研究报告，在持续注意反应任务（SART）中，额区和顶区通道的β频段事件相关去同步（ERD）降低，运动后事件相关同步（ERS）减弱。本研究旨在在荷兰和爱尔兰队列中验证这些发现。对荷兰队列（ALS患者63例，匹配对照64例）和爱尔兰队列（ALS患者36例，对照36例）实施128通道脑电图（EEG）的随机SART，采用复Morlet小波量化非相位锁定活动，计算基线标准化的刺激后ERD和ERS，对Go试次和NoGo试次的组间差异及EEG与任务表现的关联进行检验。在两个对照队列中，SART诱发了θ频段ERS、α和β频段ERD，随后在额顶轴出现β频段ERS反弹，且NoGo试次的θERS更强、αERD更显著、βERS更弱。与既往零结果不同，两个中心的ALS患者均表现出Go试次及总准确率降低（p<0.002），爱尔兰队列的Go反应时更慢（p=0.02）；两个ALS队列在NoGo准确率、Go反应时和预期错误方面存在差异（均p=0.03）。爱尔兰ALS队列与对照相比，βERD和ERS降低，荷兰队列无此差异，重复了既往研究结果；两个中心的βERS增强均与Go反应更快相关（p<0.011）。ERD和ERS变化在爱尔兰队列中得到重复，但荷兰队列未重复，这些指标的队列差异至少部分反映了功能损害程度不同。可重复的对照发现及与运动表现的一致关联，表明这些指标可可靠捕获皮质运动网络功能障碍，支持将其作为EEG标记物监测ALS的运动功能衰退。
英文摘要
Reproducible biomarkers that monitor motor and cognitive dysfunction in amyotrophic lateral sclerosis (ALS) are needed. Previous work reported reduced beta-band event-related desynchronization (ERD) and attenuated post-movement event-related synchronization (ERS) in frontal and parietal channels during the sustained attention to response task (SART). We aimed to validate these findings in Dutch and Irish cohorts. A randomized SART with 128-channel electroencephalography (EEG) was performed in Dutch (ALS n=63; matched controls n=64) and Irish (ALS n=36; controls n=36) cohorts. Non-phase-locked activity was quantified using complex Morlet wavelets to compute baseline-normalized post-stimulus ERD and ERS. Group differences and EEG associations with task performance were examined for Go and NoGo trials. In both control cohorts, the SART elicited theta ERS and alpha- and beta-band ERD, followed by rebound beta ERS across the frontoparietal axis, with greater theta ERS, stronger alpha ERD, and weaker beta ERS on NoGo than Go trials. In contrast to previous null findings, people with ALS showed reduced Go and total accuracy in both centres (p<0.002) and slower Go responses in the Irish cohort (p=0.02). The ALS cohorts differed in NoGo accuracy, Go response time, and anticipation errors (all p=0.03). Replicating prior work, the Irish ALS cohort showed reduced beta ERD and ERS versus controls, with no such differences in the Dutch cohort. Greater beta ERS was associated with faster Go responses in both centres (p<0.011). ERD and ERS changes replicated in the Irish but not the Dutch cohort. Cohort differences in these metrics reflected, at least in part, varying functional impairment. Reproducible control findings and consistent associations with motor performance indicate reliable capture of cortical motor network dysfunction, supporting these measures as EEG markers of motor decline in ALS.
