AI 中文总结
该研究对比DLPC与DOPC单分子层，明确脂质酰基链结构通过影响局部相互作用、集体界面组织及迁移率调控胆甾相液晶的界面锚定与条纹形貌，为响应型液晶界面提供设计原理。
AI 中文摘要
基于液晶的生物传感器利用界面锚定对分子吸附的敏感性，胆甾相液晶尤为有用，因其螺旋结构支持多种光学特性不同的织构，且会随锚定强度演变。本文对比饱和的1,2-二月桂酰-sn-甘油-3-磷酰胆碱（DLPC）与不饱和的1,2-二油酰-sn-甘油-3-磷酰胆碱（DOPC）单分子层，探究脂质酰基链结构如何调控界面组织与指向矢排列。通过绘制脂质浓度、混合比例、胆甾相螺距及限域范围内的条纹间距，发现指纹织构向垂直锚定排列的转变同时依赖于脂质结构与集体界面组织。DLPC产生相对规整的织构，且在高覆盖度下更易促进螺旋解旋，这与其空间更均匀的集体锚定特性一致；含DOPC的界面呈现更大的形貌异质性，这与其长链产生的强局部锚定及顺式不饱和导致的欠均匀组织一致。FRAP测量提供了荧光探针迁移率的补充信息，两种体系中，高脂质浓度下探针迁移率均受到强限制；螺距与膜厚度的变化进一步调控响应，产生共存的规整、畸变及富脂质织构。综上，这些结果表明脂质酰基链结构通过影响局部相互作用、集体界面组织及迁移率来调控胆甾相锚定，为响应型液晶界面提供了设计原理。
英文摘要
Liquid crystal-based biosensors exploit the sensitivity of interfacial anchoring to molecular adsorption. Cholesteric liquid crystals are especially useful because their helical structure supports multiple optically distinct textures that evolve with anchoring strength. Here, we compare saturated 1,2-dilauroyl-sn-glycero-3-phosphocholine (DLPC) and unsaturated 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) monolayers to determine how lipid acyl chain structure governs interfacial organization and director alignment. Mapping stripe spacing across lipid concentration, mixing ratio, cholesteric pitch, and confinement shows that the transition from fingerprint textures toward homeotropic alignment depends on both lipid structure and collective interfacial organization. DLPC produces comparatively regular textures and more readily promotes helix unwinding at high coverage, consistent with more spatially uniform collective anchoring. DOPC-containing interfaces show greater morphological heterogeneity, consistent with strong local anchoring from longer tails together with less uniform organization arising from cis-unsaturation. FRAP measurements provide complementary information on fluorescent-probe mobility, which becomes strongly restricted at high lipid concentration for both systems. Variations in pitch and film thickness further modulate the response, producing coexisting regular, distorted, and lipid-enriched textures. Together, these results show that lipid acyl chain structure regulates cholesteric anchoring through its effects on local interactions, collective interfacial organization, and mobility, providing design principles for responsive liquid-crystal interfaces.
