金属ens立体光学触诊用于癌症力学成像
Metalens stereoscopic optical palpation for imaging cancer mechanics
浏览论文内容
中文总结 AI 辅助
该研究提出金属ens立体光学触诊（MSOP）平台，通过纳米光子技术实现高保真自对准弹性成像，可精准界定术中肿瘤切缘以降低再切除率。
中文摘要 AI 辅助
准确的术中切缘评估对于实体瘤的完整切除至关重要，但外科医生通常依赖主观的手动触诊，该方法空间分辨率差，而术前成像缺乏实时反馈。新兴的光学弹性成像技术虽能提供定量力学对比度，但其依赖的大型光学组件需要繁琐的对准过程，且难以集成到小型手术器械中。在此，我们报道金属ens立体光学触诊（MSOP），这是一种纳米光子成像平台，利用集成了单颗CMOS传感器的双目金属ens实现高保真、自对准的弹性成像。通过用紧凑的立体结构替代复杂的体光学元件，MSOP可实现组织表面应力的稳健、高对比度映射。在异质硅胶体模中验证后，我们通过表征新鲜小鼠胰腺癌模型及切除的人乳腺、肝脏标本中的恶性肿瘤力学特征，证明了MSOP的转化潜力。MSOP可在不同肿瘤学场景中提供可靠、无标记的力学对比度，为精准术中切缘界定提供了紧凑工具，以降低再切除率并改善手术结局。
英文摘要
Accurate intraoperative margin assessment is critical for complete resection of solid tumours. However, surgeons routinely rely on manual palpation, which is highly subjective and fundamentally limited by poor spatial resolution, and pre-operative imaging lacks real-time feedback. While emerging optical elastography techniques offer quantitative mechanical contrast, their reliance on bulky optical components necessitates cumbersome alignment and hinders integration into miniaturised surgical instruments. Here, we report metalens stereoscopic optical palpation (MSOP), a nanophotonic imaging platform leveraging a binocular metalens integrated with a single CMOS sensor to achieve high-fidelity, self-aligned elastography. By replacing complex bulk optics with a compact stereoscopic architecture, MSOP enables robust, high-contrast mapping of tissue surface stress. Following validation in heterogeneous silicone phantoms, we demonstrate MSOP's translational potential by characterising the mechanical signatures of malignancies in fresh mouse pancreatic cancer models, as well as excised human breast and liver specimens. By providing reliable, label-free mechanical contrast across diverse oncological landscapes, MSOP offers a compact tool for precise intraoperative margin delineation to reduce re-excision rates and improve surgical outcomes.
