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一种非线性动力学方法用于评估无创人体胃电图记录中的幅频耦合

A nonlinear dynamics approach to assess amplitude-frequency coupling in non-invasive human electrogastrography recordings

Akshita A. Rao, Todd P. Coleman

arXiv 2608.23613首次发表:更新:

AI 中文总结

该研究提出统计非线性动力学框架以评估胃电图的幅频耦合,其度量可区分健康人与胃功能障碍者,为胃电图分析提供了补充性动力学特征。

AI 中文摘要

常规胃电图(EGG)分析通过主频、功率或基于相位的指标总结胃慢波活动,未明确建模依赖振幅的频率动力学。我们开发了一种统计非线性动力学框架,将胃带解析EGG信号表示为随机Stuart-Landau振子,并估计局部有效相位剪切β_eff,这是一种幅频耦合的归一化度量。在60名健康参与者的夜间记录中,有效相位剪切始终为负,可泛化到每份记录的保留部分,且被破坏振幅-相位对齐但保留振幅序列结构的振幅替代物消除。随后我们将该度量应用于16名健康参与者和24名胃功能障碍参与者的空腹与餐后记录,发现各组间相位剪切幅度存在差异,其分类功能障碍的效果与最强的多电极基于相位的行波度量相当。这些发现确立了幅频耦合作为胃带EGG的动力学特征,可补充常规频谱和空间相位度量,同时推动未来多通道观测模型以确定其与慢波传播及胃功能的关系。

英文摘要

Conventional electrogastrography (EGG) analyses summarize gastric slow-wave activity using dominant frequency, power, or phase-based metrics, without explicitly modeling amplitude-dependent frequency dynamics. We developed a statistical nonlinear-dynamics framework that represents the gastric-band analytic EGG signal as a stochastic Stuart-Landau oscillator and estimate local effective phase-shear, $β_{\mathrm{eff}}$, a normalized measure of amplitude-frequency coupling. In overnight recordings from 60 healthy participants, effective phase-shear was consistently negative, generalized to held-out halves of each recording, and was abolished by amplitude surrogates that disrupted amplitude-phase alignment while preserving amplitude-series structure. We then applied the measure to fasted and fed recordings from 16 healthy participants and 24 participants with gastric dysfunction. Phase-shear magnitude differed between groups and classified dysfunction comparable to the strongest multielectrode phase-based traveling-wave measures. These findings establish amplitude-frequency coupling as a dynamical feature of gastric-band EGG that complements conventional spectral and spatial phase metrics, while motivating future multichannel observation models to determine its relationship to slow-wave propagation and gastric function.

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