反对称驱动的声流体流通装置中提高吞吐量
Increased throughput in antisymmetrically actuated acoustofluidic flow-through devices
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中文总结 AI 辅助
本研究通过实验与数值模拟证实，反对称驱动的声流体装置在相同电输入功率下，较对称驱动具有更高的声聚焦效率与稳健性，可用于提高生物分离的吞吐量。
中文摘要 AI 辅助
低丰度生物对象的分离需要高通量才能实现声流体系统的实际应用。若能成比例提高声能密度，提高流速有助于实现高通量，而这可通过换能器与装置的高效耦合实现。特别是，使用两个反相电极的反对称驱动在理论上被证明可提高装置的声能密度。本研究结合实验与三维数值模拟，探究声流体系统的对称驱动与反对称驱动机制。声聚焦实验表明，在相同电输入功率下，反对称驱动模式的性能优于对称驱动，量化指标为聚焦粒子形成带的归一化宽度。对两种驱动模式的粒子带宽进行数值模拟，结果显示反对称驱动模式比对称驱动模式更稳健，对系统几何对称特性的依赖性较弱。模拟结果验证了实验发现，表明反对称驱动可提高声泳效率与稳健性，适用于高通量应用。
英文摘要
Separation of low-abundance biological objects requires high throughput for practical use of an acoustofluidic system. Increasing the flow rate helps in achieving high-throughput if the acoustic energy density can be increased proportionally, and this may be possible with an efficient coupling of the transducer to the device. In particular, antisymmetric actuation using two electrodes with opposite phases is theoretically proven to enhance the acoustic energy density of the device. In this work, we study the symmetric and antisymmetric actuation mechanisms of an acoustofluidic system using both experiments and three-dimensional numerical simulations. The acoustic focusability experiments show that under the same electrical input power, the antisymmetric actuation mode performs better than the symmetric actuation, quantified in terms of the normalized width of the band formed by the focused particles. Numerical simulations of this particle bandwidth are performed for both actuation modes, and the results suggest that the antisymmetric actuation mode is more robust than the symmetric one, being weakly dependent of the geometric symmetry properties of the system. The simulation results corroborate the experimental findings, which indicate that the antisymmetric actuation increases the acoustophoretic efficiency and robustness for high-throughput applications.
