搏动分辨视网膜动脉多普勒全息速度波形的低秩模态端点可表征对闪烁刺激的反应
Low-rank modal endpoints from beat-resolved retinal arterial Doppler holography velocity waveforms characterize the response to flicker provocation
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中文总结 AI 辅助
该研究结合搏动分辨视网膜多普勒全息术与低秩模态分解，通过分析33组视网膜采集数据，发现13Hz闪烁会改变动脉搏动模态相关的多个指标，可表征对闪烁刺激的反应。
中文摘要 AI 辅助
传统视网膜闪烁终点量化直径、平均速度或流量的变化，但无法捕捉神经血管刺激期间心脏速度波形的模态集中度。本研究将搏动分辨视网膜多普勒全息术与低秩模态分解相结合，从跨搏动和血管位置采样的未过滤动脉段速度波形中推导紧凑的动脉端点。对于每次采集，将局部中心化波形组装为公共矩阵并通过奇异值分解（SVD）分解；稳健统计量可量化总搏动尺度、模态振幅、残差振幅、平均-搏动平衡及奇异谱维度，该结构也可描述性应用于单个搏动。我们对单只眼睛的33个时间有序采集（基线1/闪烁/基线2）验证该框架：与合并基线相比，13Hz闪烁与更低的中心化波形RMS尺度R₀及主导模态振幅A₁相关，与更高的稳健残差振幅比ρ₁、ρ₂，平均-搏动比MPR，有效秩及参与比相关；这些对比经Holm校正后显示出会话内探索性分离，未检测到绝对残差振幅R₁、R₂的差异。上述观察结果与特定采集的主导动脉搏动模态集中度降低一致，而非绝对残差搏动性增加。
英文摘要
Conventional retinal flicker endpoints quantify changes in diameter, mean velocity, or flow but do not capture the modal concentration of the cardiac velocity waveform during neurovascular stimulation. Here, beat-resolved retinal Doppler holography and low-rank modal decomposition are combined to derive compact arterial endpoints from unfiltered arterial segment-velocity waveforms sampled across beats and vessel locations. For each acquisition, locally centered waveforms are assembled into a common matrix and decomposed by singular-value decomposition (SVD). Robust summaries quantify total pulsatile scale, modal amplitude, residual amplitude, mean-to-pulsatile balance, and singular-spectrum dimensionality; the same construction can also be applied descriptively to individual beats. We demonstrate the framework using 33 temporally ordered Baseline~1/Flicker/Baseline~2 acquisitions from one eye. Relative to the pooled baselines, 13-Hz flicker was associated with lower centered-waveform RMS scale $R_0$ and leading-mode amplitude $A_1$, and with higher robust residual-amplitude ratios $ρ_1$ and $ρ_2$, mean-to-pulsatile ratio MPR, effective rank, and participation ratio; these contrasts showed exploratory within-session separation after Holm adjustment. No evidence of differences in the absolute residual amplitudes $R_1$ and $R_2$ was detected; together, these observations are consistent with reduced concentration in the leading acquisition-specific arterial pulse mode rather than an increase in absolute residual pulsatility.
