发表机构
Wyant College of Optical Sciences, University of Arizona; The Institute for Translational Sciences, University of Texas Medical Branch（亚利桑那大学怀雅特光学科学学院; 德克萨斯大学医学分校转化科学研究所）
机构由 AI 辅助整理，请以论文原文为准。AI 中文总结
该研究开发了通过单步双光子3D打印制成的全光纤集成内窥镜OCT探针，采用系统级集成策略，实现即插即用更换，性能稳定，可用于离体生物样本成像，降低了内窥镜OCT的应用门槛。
AI 中文摘要
光学相干断层扫描（OCT）可对微观结构进行深度分辨、无标记成像，已成为光学活检的核心 modality。将该技术从台式仪器拓展至小腔道、介入工具、神经接口及受限工程结构，需要探针具备微型化、可定制、低成本、易更换和易操作的特性。当前内窥镜OCT探针受限于复杂的组件链、繁琐的光纤加工及参考臂匹配，这些都增加了系统成本和用户专业要求。本文展示了一种全光纤集成OCT（F2I-OCT）探针，其中单个双光子聚合元件构成了完整的远端干涉架构。光束扩束、侧视转向、聚焦及共光路参考生成功能被集成在一个打印的微光学体内，同时仍保持独立可设计性。该架构将探针制造从光纤加工和干涉仪调谐转变为打印-键合工艺，消除了熔接、精密 cleaving 及单探针系统调整。由于每个探针自带参考，可在未修改的OCT系统上以即插即用方式更换。连续组装的20个探针表现出可重复性能，返回参考功率的标准差低于0.15 dB。系统灵敏度达93 dB以上，可分辨离体气道和牙髓腔样本的分层结构。通过打印完整的远端干涉架构而非独立微透镜，本研究为微型OCT建立了系统级集成策略，降低了可部署内窥镜成像的门槛，并为临床筛查、图像引导介入、神经技术及受限空间检测提供了专用探针。
英文摘要
Miniature probes extend optical coherence tomography (OCT) into lumens and other confined spaces, but conventional implementations often rely on multiple distal components, fiber processing, and probe-specific interferometer matching. Here, a fully fiber-integrated OCT (F2I-OCT) architecture is demonstrated in which two-photon microfabrication defines not only the terminal imaging optic, but the complete distal optical and interferometric architecture within a single fiber-mounted element. Beam expansion, side-view redirection, common-path reference generation, and terminal imaging are physically integrated while remaining independently designable. This architecture transfers complexity from component fabrication and interferometer matching into three-dimensional optical design, reducing assembly to a print-and-bond process and enabling plug-and-play exchange on the same OCT platform. Terminal optics can be adapted to different working distances, surrounding media, and wavefront transformations without redesigning the upstream architecture. Twenty assembled probes exhibit returned-reference and side-viewing-output power standard deviations of 0.149 dB and 0.071 dB, respectively. The system achieves 93.1 dB sensitivity and enables ex vivo imaging of airway and dental structures. The combination of a common plug-and-play architecture with broad optical design freedom provides a versatile platform for endoscopic and confined-space imaging across diverse biomedical and technical environments.
