AI 中文总结
采用无网格膜模拟（非格点活性Potts模型），发现蛋白质结合/解离循环可诱导闪烁畴，该畴在无张力膜中即可形成，区别于热平衡下需正表面张力的六边形凸畴。
AI 中文摘要
本文采用无网格膜模拟研究非平衡膜图案形成。结合的蛋白质被认为具有两种状态，可产生不同的膜自发曲率。由于化学势差，蛋白质结合和解离循环发生，作为一种非格点活性Potts模型。研究发现，这种循环结合/解离可诱导闪烁畴，其大小振荡：具有较高自发曲率的蛋白质凸畴生长，随后蛋白质转变为具有较低自发曲率的另一状态，导致畴收缩，该过程重复进行。热平衡时，弯曲能与表面张力竞争形成六边形凸畴，仅在正表面张力下稳定形成；但闪烁畴甚至可在无张力膜中形成。
英文摘要
Nonequilibrium membrane pattern formation is studied using meshless membrane simulation. Bound proteins are considered to have two states that generate different membrane spontaneous curvatures. Protein binding and unbinding occur cyclically owing to chemical potential differences, as an off-lattice active Potts model. It is found that this cyclic binding/unbinding can induce blinking domains, with oscillating size: convex domains of the proteins with a higher spontaneous curvature grow, and subsequently, the proteins change to the other state with a lower spontaneous curvature, resulting in domain shrinkage. These processes repeat. In thermal equilibrium, hexagonal convex domains are formed by the competition between bending and surface tension energies, so that they are stably formed only under positive surface tension. However, blinking domains can form even in tensionless membranes.
Comments8 pages, 10 figures
