AI 中文总结
该研究通过计算建模发现，精神疲劳时ATP水解供能减少会损害蛋白质α-螺旋的酰胺I激子协同效应，改变神经元电生理特性，削弱大脑信息处理能力，建议智力工作中间歇性恢复以保护健康和生产力。
AI 中文摘要
背景：随着皮层神经元从休息状态逐渐过渡到疲劳状态，大脑信息处理能力会下降。主观上，疲劳表现为疲惫、乏力或精力不足，降低安全有效工作的能力。目的：本理论论文指出大脑疲劳的物理起源在于生化反应商和跨膜离子浓度梯度逐渐恶化，这会增加神经元兴奋性并降低大脑皮层的信噪比。方法：通过成熟的数据驱动计算机模型，对比休息状态与疲劳状态下的大脑表现，这些模型用于研究热噪声存在时蛋白质α-螺旋内部的能量传输，涉及不同ATP能量状态，或静息膜状态与疲劳状态下电刺激引起的锥体细胞动作电位发放。结果：我们发现ATP水解导致的吉布斯自由能供应减少会损害蛋白质α-螺旋内部传播的酰胺I激子之间的协同效应，导致分子孤子的热稳定性下降。同时，Na+或K+离子的能斯特反转电位变化，进一步导致精神疲劳期间神经元过度兴奋和神经元去极化阻滞的风险升高。结论：详细的计算建模表明，ATP能量状态下降导致的蛋白质功能低效，改变了单个神经元的电生理特性，从而损害其执行认知任务的信息处理能力。在智力挑战性工作中安排间歇性恢复休息状态的实践，可保护身心健康，预防倦怠并提高长期生产力。
英文摘要
Background: Brain information processing deteriorates as cortical neurons gradually transition from a rested state into fatigue. Subjectively, fatigue is experienced as a state of weariness, tiredness, or lack of energy that reduces the ability to work safely and effectively. Objective: In this theoretical paper, we pinpoint the physical origin of brain fatigue in the gradual deterioration of biochemical reaction quotients and transmembrane ion concentration gradients, which increase neuronal excitability and decrease the signal-to-noise ratio in the brain cortex. Methods: Brain performance in a rested state versus fatigue is examined by well-established, data-driven computer models for energy transport inside protein $α$-helices in the presence of thermal noise for different ATP energy states or for pyramidal neuron firing of action potentials under electric stimulation in a rested membrane state versus fatigue. Results: We found that reduced Gibbs free energy supply from ATP hydrolysis impairs the cooperative effect between amide I excitons propagating inside protein $α$-helices, with resulting decreased thermal stability of molecular solitons. Concurrent changes in Nernst reversal potentials for Na+ or K+ ions further led to neuronal hyperexcitability and a higher risk of neuronal depolarization block during mental fatigue. Conclusions: Detailed computational modeling showed that inefficient protein function due to diminished ATP energy status, alters the electrophysiological properties of individual neurons, thereby impairing their information processing capacity for the proper execution of cognitive tasks. Scheduling practices aimed at intermittent recovery of the rested brain state during intellectually challenging work could protect physical and mental wellbeing, prevent burnout, and enhance long-term productivity.
Comments21 pages, 4 figures, 1 table
Journal refFatigue: Biomedicine, Health & Behavior 2026; 14 (3): 216-233
DOI：10.1080/21641846.2026.2636450
