双折射生物矿物微载体稳定液体中的多模态纳米金刚石量子传感
Biocompatible Vaterite Carriers Enable Multimodal Quantum Sensing with Nanodiamonds
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中文总结 AI 辅助
本研究利用双折射球文石微球作为载体，组装氮空位纳米金刚石，开发杂化平台实现液体中多模态量子传感，可用于磁场与质子浓度、pH值检测，性能优异。
中文摘要 AI 辅助
液体中的移动纳米金刚石量子传感器受布朗旋转、可变光子收集以及光阱引入的扰动限制。本研究将40纳米的氮空位（NV）纳米金刚石组装在多孔双折射球文石微球的表面，这种碳酸盐生物矿物提供了偏振可寻址的主体框架、各向异性发射重分布以及质子活性热力学界面。在976纳米光阱下，该杂化物保留了其自旋共振和纵向弛豫，共振对比度变化小于7%，在0.8瓦时共振中心偏移约1兆赫。塞曼分裂共振可实现0至0.8毫特斯拉的磁场传感，响应指标为78-144微特斯拉每平方根赫兹。在缓冲细胞培养基中，10.7微摩尔标称质子当量剂量将T1从23.4±2.3微秒缩短至9.0±1.2微秒，对应DMEM中的浓度灵敏度为6.46微摩尔每平方根赫兹、pH灵敏度为6.54毫pH每平方根赫兹；相比之下，乙醇中500倍更高的质子剂量产生的自旋响应弱得多，凸显了富碳酸盐界面的作用。本研究开发了巨正则电荷调控模型，将质子化学势与NV光谱窗口内的界面切换动力学耦合，捕捉介质依赖的动态质子转导。通过整合取向稳定、光操纵、磁传感和界面化学响应，该富碳酸盐杂化平台为复杂生物液体中的多模态量子传感建立了通用方法。
英文摘要
Mobile nanodiamond quantum sensors in liquids are affected by Brownian rotation, variable photon collection, and perturbations from optical trapping. Here we assemble 40-nm nitrogen-vacancy nanodiamonds on porous, birefringent vaterite microspherulites, creating mobile sensors with a polarization-addressable body frame and a chemically active carbonate interface. Under 976-nm trapping, the sensors retain spin resonance and longitudinal relaxation, with less than 7% variation in contrast and an approximately 1-MHz resonance shift at 0.8 W. Zeeman-split resonances resolve magnetic fields from 0 to 0.8 mT, with a response metric of 78--144 $μ$T Hz$^{-1/2}$. In cell-culture medium, a 10.7-$μ$M proton-equivalent dose shortens $T_1$ from $23.4 \pm 2.3$ to $9.0 \pm 1.2$ $μ$s, yielding concentration and pH sensitivities of $6.46$ $μ$M Hz$^{-1/2}$ and $6.54$ mpH Hz$^{-1/2}$, respectively. A 500-fold larger proton dose in ethanol produces a weaker response. A grand-canonical charge-regulation model links proton chemical potential to interfacial switching, establishing a route to multimodal quantum sensing in complex liquids.
