发表机构
Hospital for Special Surgery（特种外科医院）
机构由 AI 辅助整理，请以论文原文为准。AI 中文总结
该研究开发基于nnU-Net和定制几何算法的方法，从ZTE MRI自动提取FAI相关角度，其在多数角度上与专家手动测量结果一致性良好，证实全自动骨形态测量评估的可行性。
AI 中文摘要
计算机断层扫描（CT）仍是股骨髋臼撞击综合征（FAI）三维骨形态测量的参考标准，但需电离辐射且依赖手动测量。零回波时间（ZTE）MRI可显示皮质骨，其生成的FAI角度与CT结果一致，但自动角度提取仍存在局限。本研究为横断面研究（证据等级3），开发并验证了从ZTE MRI自动计算FAI角度的方法，并评估其与专家手动测量的一致性。研究纳入73名受试者（平均年龄36.8±18.5岁，51名女性、22名男性），共获取135个髋关节的骨盆ZTE MRI图像。采用nnU-Net在100个经人工标注的髋关节图像上训练，以分割股骨、骨盆及三个骨性标志点；通过定制几何算法从推断的分割结果计算α角、股骨颈干角、Tonnis角、冠状位及矢状位中心边缘角、髋臼前倾角。将35个测试髋关节的测量结果与两名放射科医师手动测量的均值进行比较，采用组内相关系数（ICC）和Bland-Altman分析评估一致性。骨的Dice系数超过0.96，标志点的Dice系数为0.65至0.83；标志点中位误差为股骨头0.38mm、外侧髋臼0.82mm、内侧髋臼及大转子均小于2.5mm。医师间ICC在髋臼前倾角、冠状位中心边缘角及Tonnis角方面表现优异（≥0.82），而在α角及股骨颈干角方面较差；模型与医师均值的一致性在髋臼前倾角、冠状位中心边缘角及Tonnis角方面表现优异（0.92-0.96），在髋臼中部矢状位中心边缘角方面表现良好（0.74），在α角及股骨颈干角方面表现一般（0.45、0.55）。多数角度的模型Bland-Altman一致性限窄于医师间一致性限。研究表明，从ZTE MRI进行全自动形态测量评估是可行的，且在多数覆盖角及前倾角方面表现与专家阅片者相当。
英文摘要
Computed tomography (CT) remains the reference for 3D osseous morphometry in femoroacetabular impingement (FAI) but requires ionizing radiation and manual measurement. Zero echo time (ZTE) MRI visualizes cortical bone and yields FAI angles that agree with CT, but automated angle extraction remains limited. We developed and validated automated FAI angle computation from ZTE MRI and assessed agreement with expert manual measurements in a cross-sectional study (level of evidence, 3). Pelvic ZTE MRI was acquired in 73 participants (mean age 36.8 +/- 18.5 years; 51 women, 22 men), yielding 135 hips. nnU-Net was trained on 100 manually curated hips to segment the femur, pelvis, and three osseous landmarks. Custom geometric algorithms computed alpha, femoral neck-shaft, Tonnis, coronal and sagittal center-edge, and acetabular version angles from inferred segmentations. Measurements on 35 test hips were compared with the mean of two radiologists' manual measures using intraclass correlation (ICC) and Bland-Altman analysis. Dice exceeded 0.96 for bone and ranged from 0.65 to 0.83 for landmarks. Median landmark error was 0.38 mm (femoral head), 0.82 mm (lateral acetabulum), and <2.5 mm (medial acetabulum, greater trochanter). Interrater ICC was excellent for acetabular version, coronal center-edge, and Tonnis (>=0.82) but poor for alpha and femoral neck-shaft. Model versus rater-mean agreement was excellent for acetabular version, coronal center-edge, and Tonnis (0.92-0.96), good for mid-acetabular sagittal center-edge (0.74), and fair for alpha (0.45) and femoral neck-shaft (0.55). Model Bland-Altman limits of agreement were narrower than interrater limits for most angles. Fully automated morphometric assessment from ZTE MRI is feasible and performs comparably to expert readers for most coverage and version angles.
