用于子宫层分割的无监督对抗域自适应：从带标签的电影MRI到无标签的动态EPI MRI
Unsupervised Adversarial Domain Adaptation for Uterine layer Segmentation: From Labeled Cine to Unlabeled Dynamic EPI MRI
- Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg（埃尔朗根-纽伦堡大学弗里德里希-亚历山大分校埃尔朗根大学医院放射学研究所）
- CAIMED（CAIMED机构）
- L3S（L3S机构）
- Institut für Informationsverarbeitung, Leibniz University Hannover（汉诺威莱布尼茨大学信息处理研究所）
机构由 AI 辅助整理，请以论文原文为准。
AI总结：
该研究针对子宫层分割问题，提出无监督对抗域自适应框架，迁移电影MRI的分割知识至动态EPI MRI，结合Unet-LSTM与多尺度域判别器，实现了良好的分割效果，为探究子宫收缩性与T2*变化的关联提供了可行方法。
AI中文摘要：
子宫蠕动是一种关键的生理现象，负责月经周期的多种功能，与子宫壁的微观结构密切相关。子宫运动和组织特性的改变与妇科疾病的病因有关，但这些过程此前一直被孤立研究。我们引入了一种动态多回波梯度回波EPI框架，用于在0.55T场强下同时表征和关联子宫蠕动活动与时间分辨的T2*变化。固有磁化率伪影、分辨率降低以及手动子宫层标注的负担，可通过无监督对抗域自适应框架解决，该框架将分割知识从带标签的电影MRI迁移至无标签的动态EPI。我们实现了Unet-LSTM与多尺度域判别器，利用了时间层动态特征。实验取得了0.88的Dice分数和0.80的Jaccard指数。子宫肌层、结合带和子宫内膜的平均T2*值分别为108ms、76ms和124ms。在39例病例中的14例中观察到结合带面积与T2*呈负相关，为结合带收缩和运动相关的氧合模式提供了初步见解，证明了评估收缩性与动态T2*变化之间相互作用的可行性。
英文摘要：
Uterine peristalsis is a key physiological phenomenon responsible for various functions across the menstrual cycle, intimately linked to uterine wall microstructure. Alterations in uterine motion and tissue properties are implicated in the etiology of gynecological diseases, yet these processes have been studied in isolation. We introduce a dynamic multi-echo gradient echo EPI framework for simultaneous characterization and correlation of uterine peristaltic activity and time-resolved T2* changes at 0.55T. Inherent susceptibility artifacts, reduced resolution, and burden of manual uterine layer annotation are addressed by an unsupervised adversarial domain adaptation framework, transferring segmentation knowledge from labeled cine MRI to unlabeled dynamic EPI. We implemented Unet-LSTM with multi-scale domain discriminators that exploits temporal layer dynamics. A Dice score of 0.88 and Jaccard index of 0.80 was achieved. Mean T2* values were 108ms, 76ms, and 124ms for the myometrium, junctional zone, and endometrium. A negative correlation between junctional zone area and T2* was observed in 14/39 cases, providing first insights into oxygenation patterns associated with junctional zone contraction and motion, demonstrating feasibility of assessing the interplay between contractility and dynamic T2* changes.
