AI 中文总结
Spectacular是一款以Xilinx Zynq片上系统为核心的模块化DAQ系统，可优化微剂量学读出电子设备与传感器的测试，已在离子治疗设施中成功验证，助力微剂量学融入临床常规实践。
AI 中文摘要
采用质子、氦离子或碳离子等轻离子的粒子治疗，可在精准靶向肿瘤的同时，借助增强的生物学效应最大限度减少对健康组织的损伤。成功的治疗规划不仅取决于吸收剂量，还取决于辐射品质，该品质通过线性能量转移（LET）量化。微剂量学通过测量入射粒子在代表相关生物尺度的微米级固态探测器中沉积的能量，直接实验确定这类量。然而，治疗离子束中的小信号幅度和高粒子率对现有读出系统构成挑战，现有系统在 pileup（堆积）和信噪比（SNR）方面未充分优化以实现可靠运行。为解决该问题，开发了一种模块化数据采集（DAQ）系统，用于加速微剂量学及相关光谱应用中定制读出电子设备和传感器表征的设计。该系统以Xilinx Zynq片上系统为核心，结合实时处理、高带宽流传输和高分辨率数字化（100 MSa/s下16位），以实现先进的数字信号处理。该平台集成了可编程电源、偏置电压滤波器、测试脉冲发生器和灵活I/O。探测器和前置放大器前端搭载于可互换的子板上，子板通过标准化接口连接，允许在同一平台上评估不同的硬件配置和读出算法。Spectacular DAQ系统已在MedAustron离子治疗设施中，搭配定制电荷灵敏前置放大器和金刚石微剂量计成功测试。通过实现不同读出电子设备和传感器的优化快速测试，该系统支持并推进微剂量学在常规临床实践中的整合。
英文摘要
Particle therapy using light ions like protons, helium ions or carbon ions enables precise tumor targeting with enhanced biological effectiveness while minimizing damage to healthy tissue. Successful treatment planning depends not only on the absorbed dose but also on quality of the radiation, as quantified by the linear energy transfer (LET). Microdosimetry provides a direct experimental determination of such quantities by measuring the energy deposited per incoming particle in micrometer-sized solid-state detectors representing the relevant biological scales. However, the small signal amplitudes and high particle rates in therapeutic ion beams challenge existing readout systems, which are not sufficiently optimized for reliable operation with respect to pileup and signal-to-noise ratio (SNR). To address this, a modular data acquisition (DAQ) system was developed to accelerate the design of custom readout electronics and sensor characterization in microdosimetry and related spectroscopic applications. Centered around a Xilinx Zynq system-on-chip, it combines real-time processing, high-bandwidth streaming, and high-resolution digitization (16 bit at 100 MSas$^{-1}$) to enable advanced digital signal processing. The platform integrates programmable power supplies, a bias-voltage filter, test-pulse generators, and flexible I/O. Detector and preamplifier front-ends are hosted on interchangeable daugtherboards connected via a standardized interface, allowing different hardware configurations and readout algorithms to be evaluated on the same platform. The Spectacular DAQ system was successfully tested at the MedAustron ion therapy facility with custom charge-sensitive amplifiers and a diamond microdosimeter. First results demonstrate the feasibility and provide a proof-of-concept for potential future applications in clinical practice.
CommentsResubmitted to JINST after minor revisions
