AI 中文总结
本研究开发采用电磁跟踪手持探头的融合电阻抗断层成像方法，经模拟与体模实验验证，可将口腔癌边界定位精度提升至0.5mm内，融合差分EIT抗噪性最优，为临床可部署的阻抗成像技术奠定基础。
AI 中文摘要
研究背景与问题：口腔鳞状细胞癌（OSCC）切除术中切缘阳性情况常见，会显著影响患者预后，电阻抗断层成像（EIT）可在术中区分癌组织与健康组织；本研究旨在开发并验证一种融合EIT方法，利用手持电阻抗探头记录的多次阻抗测量数据，准确重建肿瘤边界。方法：通过模拟与噪声分析研究融合EIT的最佳重建方法，并开展实测体模实验评估EIT重建效果。主要结果：融合方法可从多个探头位点成功且准确地重建电导率边界位置，模拟与实验结果均显示边界定位精度可达真实边界的0.5mm以内；模拟与噪声分析表明，所有重建方法在半平面边界场景下添加噪声后仍保持较强分类精度，其中融合差分EIT因重建公式中高数据冗余性，对各类添加噪声的鲁棒性最强。意义：实测多位点探头实验为开发可结合多位置EIT数据提升边界定位精度的方法奠定了重要基础，该研究成果向临床可部署的阻抗成像技术迈出了一步，该技术可用于扫描整个肿瘤边界，有望显著改善OSCC的手术预后。
英文摘要
Objective: Positive margins in oral squamous cell carcinoma (OSCC) resection are common and significantly impact patient outcomes. Electrical impedance tomography (EIT) can be used to intraoperatively distinguish cancer from healthy tissue. The objective of this study was to develop and identify a fused EIT approach to accurately reconstruct a tumor boundary using multiple impedance measurements recorded with a handheld electrical impedance probe. Approach: Simulations and noise analyses were used to investigate the best reconstruction method for fused EIT, and a measured phantom experiment was conducted to evaluate the EIT reconstructions. Main results: Fused approaches successfully and accurately recovered the conductivity boundary location from multiple probe sites, increasing boundary localization to within 0.5 mm of the true boundary for both simulated and experimental results. Simulations and noise analysis revealed that all reconstruction methods maintain strong classification accuracy with added noise on a half-plane boundary scenario and fused difference EIT is the most robust to all types of added noise, due to the high data redundancy in the reconstruction formulation. Significance: The measured multi-site probe experiments represent important steps in the development of an approach that can combine EIT from multiple locations to increase boundary localization accuracy. Overall, this result is a step towards a clinically deployable impedance imaging approach to scanning the entire tumor boundary, which could significantly help to improve surgical outcomes for OSCC.
Comments16 pages, 6 figures, submitted to Physiological Measurements journal
