磁电核壳结构的频率解调：一种增强生物刺激的新方法
Frequency demodulation with magnetoelectric coreshells: A novel approach to enhanced bio-stimulation
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中文总结 AI 辅助
该研究提出利用磁电核壳器件的非线性特性实现频率解调与生物刺激，通过多物理场仿真和跨模型验证证实其可诱导神经细胞膜电位，有望开发为多功能局部化核壳用于生物医学领域。
中文摘要 AI 辅助
磁电（ME）核壳器件因磁致伸缩核与压电壳之间的强相互耦合，在生物传感、通信等生物医学技术领域具有有趣的应用前景，该特性可用于细胞的局部生物刺激等特定应用。本文提供了利用ME核壳器件非线性特性进行频率解调与刺激的概念验证。我们采用多物理场仿真方法，其中ME核壳由直流磁场偏置，并通过双线圈交变磁场进行扰动。ME非线性磁致伸缩与双线圈扰动的综合作用实现了干扰频率分量的解调，该分量在压电壳上诱导出等效电热点。我们进行了跨模型验证：将压电壳上产生的电流密度作为输入，提供给霍奇金-赫胥黎（HH）神经细胞模型，以主动诱导细胞的膜电位。未来有望将其开发为独立、无电池与电子器件、可控制、多功能且局部化的核壳，用于靶向药物递送、反向散射通信及生物刺激等应用。
英文摘要
Magnetoelectric (ME) coreshell devices have interesting applications in biomedical technologies including biosensing and communication, due to their strong inter-coupling between the magnetostrictive core and the piezoelectric shell. This property could be utilized for specific applications in localized bio-stimulation of cells. This paper provides a conceptual proof of using the non-linear property of ME coreshell devices for frequency demodulation and stimulation. We use the Multiphysics simulation approach, wherein the ME coreshell was biased with a DC magnetic field and perturbed through dual coil alternating magnetic fields. The combined effect of the ME non-linear magnetostriction and the dual coil perturbation resulted in the demodulation of the interference frequency component, that induced equivalent electrical hotspots on the piezoelectric shell. We provide a cross model verification, where the generated electrical current density on the piezo shell was provided as an input to a Hodgkin-Huxley (HH) neural cell model to actively induce membrane potentials on the cell. Future applications as a standalone, battery- and electronics-free, controllable, multi-functional and localized coreshells for targeted drug delivery, backscatter communication and bio-stimulation, is envisioned.
