AI 中文总结
研究生物体发育过程，利用沃丁顿表观遗传景观模型，确定细胞间旁分泌信号对组织模式的关键作用，经粗粒化模型映射到二元自旋模型，为跨尺度描述生物系统发育提供统一框架。
AI 中文摘要
尽管基因调控和环境条件存在差异，但生物体的发育通过一系列高度协调的模式形成过程进行。细胞整合不同信号以准确推断其位置，从而获得适当的身份。利用沃丁顿最初提出的表观遗传景观模型来描述细胞命运决定，我们确定了细胞间旁分泌信号在决定组织模式中所起的关键作用。随后，我们在组织尺度上系统地对模型进行粗粒化，以将其模式映射到具有自由能景观的二元自旋模型中的状态转变。我们表明，这样的景观为描述不同时空尺度上生物系统的发育提供了一个强大的统一框架。
英文摘要
Despite the variability in gene regulation and environmental conditions, development of an organism occurs through a sequence of highly coordinated patterning processes. Cells integrate different signals to accurately infer their position in order to adopt an appropriate identity. Using a model of epigenetic landscape originally proposed by Waddington to describe cell-fate determination, we establish the critical role played by juxtacrine signaling between cells in determining tissue patterns. Subsequently we systematically coarse-grain the model at the tissue scale to map its patterning to transition between states in a binary spin model having a free energy landscape. We show that such landscapes serve as a powerful unifying framework for describing development of biological systems across distinct spatio-temporal scales.
Comments10 pages, 4 figures
