AI 中文总结
研究睡眠相关强迫对脑脊液在第三脑室流动的影响，通过瞬态CFD模拟发现，该强迫改变了往复流体位移大小和残余流动相对贡献，揭示了第三脑室流体动力学组织差异及对脑室内液体交换的重要性。
AI 中文摘要
与心脏和呼吸活动相关的准周期压力脉冲在人类脑室中产生往复性脑脊液（CSF）运动。清醒时振荡流体运动较弱且更规律，而最近发现非快速眼动睡眠期间其更为夸张，表现为连续脉冲序列中的大冲洗。本研究调查这种强迫是否能诱导通过人类脑室的更大残余流动。在清醒和睡眠相关流动脉冲下对第三脑室进行瞬态CFD模拟。睡眠相关强迫产生了明显的尾侧和头侧优先路径，腔内总体再循环减少。睡眠期间相对于搏出量的流动通量从约0.540%的低值增加到28.4%。因此，睡眠相关强迫不仅改变往复流体位移的大小，还改变残余流动的相对贡献。这些发现表明第三脑室流体动力学组织的差异，并突出了这种组织对脑室内液体交换的重要性。
英文摘要
Quasi-periodic pressure pulses associated with cardiac and respiratory activity generate reciprocating cerebrospinal fluid (CSF) motion in the human ventricles. While weak and more regular during wakefulness, oscillatory fluid motions have recently been found to be much more exaggerated during NREM sleep, appearing as large flushes in successive pulse trains. The present study investigates whether this forcing can induce greater residual streaming through the human ventricles. Transient CFD simulations were performed in the third ventricle under awake and sleep-related flow pulses. Sleep-related forcing produced clear caudal and rostral preferential pathways and less overall recirculation in the cavity. The streaming flux relative to the stroke volume increased from a low value of about \(0.540\%\) to \(28.4\%\) during sleep. Thus, sleep-related forcing changes not only the magnitude of reciprocating fluid displacement but also the relative contribution of residual streaming. These findings demonstrate differences in hydrodynamic organisation in the third ventricle and highlight the importance of this organisation for intraventricular fluid exchange.
