AI 中文总结
研究提出基于磁共振构建核自旋破缺对称动力学来确定单分子水平手性的方法，实验上利用自旋极化前后对映体动力学差异实现手性识别，有助于化学和生物学领域手性诱导性质研究。
AI 中文摘要
分子手性在物理、化学、生命科学和药理学中起着至关重要的作用。当前，迫切需要在单分子水平上进行手性识别和控制，以通过恢复受系综平均干扰的信息来揭示手性相关现象的起源。磁共振（MR）方法作为结构分析的有力工具之一，在没有手性试剂的情况下对分子手性不敏感。在此，我们提出并通过实验证明了一种基于直接MR的方法，通过构建附近核自旋的破缺对称动力学来确定单分子水平的手性。原则上，在自旋动力学下，实空间中两种对映体的镜面对称性破缺表现为自旋空间中镜反射和时间反演的联合对称性破缺。实验上，两种对映体在强耦合但未极化的核自旋动力学中无法区分，但在自旋极化后打破场反转对称性的动力学结果中明显不同。我们的方法和结果将有利于化学和生物学领域中手性诱导性质的研究。
英文摘要
Molecular chirality plays a crucial role in physics, chemistry, life sciences and pharmacology. Nowadays, the chiral discrimination and control at the single-molecule level is urgently needed to reveal the origin of the chirality-relevant phenomena by recovering the information disturbed by the ensemble averaging. The method of magnetic resonance (MR), as one of powerful tools for structure analysis, is blind to the molecular chirality in the absence of a chiral reagent. Here we propose and experimentally demonstrate a direct MR-based method for determining the chirality at the single-molecule level through constructing the symmetry-breaking dynamics of nearby nuclear spins. In principle, the mirror asymmetry of two enantiomers in real space is manifested by breaking the joint symmetry of the mirror reflection and time reversal in spin space under spin dynamics. Experimentally, two enantiomers are indistinguishable from the dynamics of strongly-coupled but unpolarized nuclear spins, but diverge evidently in the dynamical results that break the field-inversion symmetry after spins are polarized. Our method and results will benefit the study of chirality-induced properties in the fields of chemistry and biology.
