在患者特异性颅内动脉瘤中轮廓神经血管系统的接触解析部署
Contact-resolved deployment of the Contour Neurovascular System in patient-specific intracranial aneurysms
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中文总结 AI 辅助
研究针对颅内动脉瘤治疗中计算模型忽略部署力学的问题，提出接触解析有限元框架，计算植入物在患者特异性血管环境中的结构力学，为相关建模建立生物力学基础，揭示平衡形态对关键因素敏感及传统方法不足。
中文摘要 AI 辅助
虽然囊内血流干扰器被广泛用于治疗宽颈颅内动脉瘤，但目前最先进的患者特异性计算模型通常通过规定预先设定的几何形状来忽略部署力学。这种捷径过于简化了真实物理过程，并错误地呈现了轮廓神经血管系统（CNS），其关键生物力学特征高度依赖路径。为解决这一限制，我们提出了一个接触解析有限元框架，该框架明确计算患者特异性血管环境中植入物部署的结构力学。将装置离散为双层交织的镍钛诺编织物并使用几何精确梁，血管壁表示为可变形的超弹性壳。非线性摩擦接触公式控制分阶段释放协议下复杂的线 - 线和线 - 壁相互作用。评估三种解剖表型表明，最终平衡形态对切向滑动阻力和垂直释放深度高度敏感。无摩擦假设允许过度的接触后滑动，而近粘条件增强锚固但限制局部顺应性。至关重要的是，传统的几何快速放置无法捕捉这些关键接触相互作用和壁支撑的机械平衡。这个部署解析框架为下游血液动力学、流固相互作用和机械生物学血栓形成建模建立了生物力学基础。
英文摘要
While intrasaccular flow disruptors are increasingly used to treat wide-necked intracranial aneurysms (IAs), many patient-specific computational workflows prescribe a pre-seated device geometry and omit deployment mechanics. This simplification is particularly restrictive for the Contour Neurovascular System (CNS), for which neck coverage, wall apposition, and post-contact motion depend on the deployment process. To address this, we present a contact-resolved finite-element framework that models CNS deployment within patient-specific IAs. We represent the device as a dual-layer interwoven Nitinol braid using geometrically exact beam models, and the aneurysm wall as a deformable hyperelastic shell. Frictional contact governs wire-wire and wire-wall interactions during staged release. The framework is demonstrated across three patient-specific anatomies. In the reference anatomy, the seated configuration is sensitive to the assumed device-wall tangential friction and to release depth relative to the aneurysm neck plane. Frictionless wall contact permits pronounced post-contact sliding, whereas finite tangential friction strongly suppresses residual pole motion. Release depth alters both the onset of wall engagement and the subsequent deployment path. Geometric placement approaches that prescribe the implanted configuration cannot recover this contact history or the associated wall-supported state. Our framework provides a mechanics-based route to deployed geometries for downstream hemodynamic, fluid-structure interaction, and mechanobiological analyses.
发表机构
- University of the Bundeswehr Munich（德国联邦国防军慕尼黑大学）
- Kiel University（基尔大学）
- University Hospital Schleswig-Holstein（石勒苏益格-荷尔斯泰因大学医院）
机构由 AI 辅助整理，请以论文原文为准。
