AI 中文总结
研究随机振荡器同步问题，开发同步昼夜节律 KaiC 分子新机制，发现相变仅取决于单振荡器相干性，揭示现有实验并预测外部变化可被补偿变化抵消，展示随机单振荡器到稳健集体节律的可调途径。
AI 中文摘要
虽然确定性振荡器中的同步已得到充分研究，但在自然和人造系统中，大多数潜在振荡器是随机的。然而，内在随机性的影响仍知之甚少。在此，我们开发了一种同步具有拓扑保护周期的昼夜节律 KaiC 分子的新机制。我们发现向同步的相变仅取决于单振荡器相干性，跨越一系列决定这种相干性的分子变化。分别检查与细胞和体外条件相关的介观和宏观数量，我们发现相变上下具有不同的标度性质。我们的结果揭示了几个现有实验，并进一步预测外部变化可通过改善单振荡器相干性的补偿变化来抵消，展示了随机单振荡器与其稳健集体节律之间的可调途径。
英文摘要
While synchronization has been well-studied in deterministic oscillators, most underlying oscillators are stochastic in both natural and man-made systems. Yet, the effects of intrinsic stochasticity remain poorly understood. Here, we develop a new mechanism for synchronizing circadian KaiC molecules that have topologically protected cycles. We find a phase transition to synchronization that depends only on the single-oscillator coherence, across a range of molecular changes that determine this coherence. Examining both mesoscopic and macroscopic numbers relevant for cellular and in vitro conditions respectively, we find different scaling properties above and below the phase transition. Our results shed light on several existing experiments and further predict that external changes can be offset by compensatory changes that improve the single-oscillator coherence - demonstrating a tunable pathway between stochastic single oscillators and their robust collective rhythms.
CommentsReplacement to correct author order in metadata (no changes to manuscript)
