从出生到青春期的狒狒大脑纵向MRI模板
Longitudinal MRI template of the baboon brain from birth to adolescence
AI总结：
该研究针对狒狒大脑从出生到青春期的发育，提出BABACOOL方法创建多模态发育图谱，生成BaBa21纵向发育模板，还提供全自动生成中间年龄模板的方法，为狒狒数据归一化及相关研究提供便利。
AI中文摘要：
狒狒是非人类灵长类动物研究中的宝贵资源。为促进比较发育神经科学研究，我们提出BABACOOL方法创建多模态发育图谱，用于生成BaBa21，即基于群体的纵向发育狒狒模板。它包含21只狒狒在出生约2周后至性成熟（5岁）的4个时间点的结构图像和组织概率图。该研究还提供了在任何中间年龄生成模板的全自动方法，为狒狒数据提供归一化目标，促进相关神经成像研究。
英文摘要：
The baboon (Papio) is an invaluable resource within nonhuman primate research, having the advantage of being a cercopithecoid (Old World monkey) with one of the largest brains among non-hominid primates. In order to facilitate comparative developmental neuroscience research, we present the BABACOOL (BAby Brain Atlas COnstruction for Optimized Labeled segmentation) approach for creating multi-modal developmental atlases, which we used to produce BaBa21, a population-based longitudinal developmental baboon template. BaBa21 is a spatio-temporal template that consists of structural (T1- and T2-weighted) images and tissue probability maps from a population of 21 baboons (Papio anubis) scanned at 4 timepoints beginning from about 2 weeks after birth and continuing to sexual maturity (5 years). Further, his study offers a fully automatic method for generating a template at any intermediate age for future age-specific group studies. This resource is made available to provide a normalization target for baboon data across the lifespan, including intermediate timepoints, and moreover facilitate neuroimaging research in baboons, comparative research with humans and nonhuman primate species for which developmental templates are available (e.g., macaques).
