AI 中文总结
研究量化纳米颗粒尺寸对光声产生效率的影响，推导相关模型，通过标记BODIPY染料的固体脂质纳米颗粒验证，为纳米材料定量光声表征及造影剂合理设计铺平道路。
AI 中文摘要
在光吸收纳米颗粒的胶体悬浮液中，金纳米颗粒的光声（PA）信号产生主要由水的热膨胀主导，而有机纳米颗粒的情况大多未被探索。在此，我们推导了一个模型，其中PA产生效率与颗粒尺寸以及与水的热弹性对比度成比例。该模型通过用几种BODIPY染料标记的固体脂质纳米颗粒进行了验证。这种实验验证为纳米材料的定量PA表征和PA造影剂的合理设计铺平了道路。
英文摘要
Photoacoustic (PA) signal generation in colloidal suspensions of optically absorbing nanoparticles is dominated by the thermal expansion of water for gold nanoparticles, but remains mostly unexplored for organic nanoparticles. Here, we derive a model where the PA generation efficiency scales with particle size and thermoelastic contrast with water. The model is validated using solid lipid nanoparticles labeled with several BODIPY dyes. This experimental validation paves the way for quantitative PA characterization of nanomaterials and rational design of PA contrast agents.
