发表机构
Queensland University of Technology(昆士兰科技大学)
机构由 AI 辅助整理,请以论文原文为准。AI 中文总结
研究上皮组织力学中细胞尺度力与组织尺度传输联系,发现维度控制此联系,长期力学弛豫率揭示非线性传输现象,其指数由微观力学和维度确定,为宏观传输现象提供新机制。
AI 中文摘要
上皮组织力学的连续统描述可用易于处理的宏观模型取代昂贵的基于个体的模拟,但细胞尺度力与组织尺度传输之间的联系仍知之甚少。我们表明维度控制此联系:长期力学弛豫率揭示广义多孔介质型非线性传输现象,\(D(\rho)\propto\rho^\gamma\)。非线性扩散率中的指数由微观力学和维度确定,为宏观传输现象提供了新物理机制。
英文摘要
Continuum descriptions of epithelial tissue mechanics can replace expensive individual-based simulations with tractable macroscopic models, yet the link between cell-scale forces and tissue-scale transport remains poorly understood. We show that dimensionality controls this link: long-time mechanical relaxation rates reveal generalized porous-media-type nonlinear transport phenomena, $D(ρ)\proptoρ^γ$. Exponents in nonlinear diffusivities are fixed by microscopic mechanics and dimensionality, providing a novel physical mechanism for emergent macroscopic transport phenomena.
Comments3 Figures, 16 Pages