arXiv 2607.034912026-07-07cond-mat.mes-hallphysics.app-ph

用于无标记增强灵敏度检测人血清白蛋白的石墨烯双电层晶体管

Graphene Electric Double-Layer Transistors for Enhanced-Sensitivity Label-Free Detection of Human Serum Albumin

University of Modena and Reggio Emilia（摩德纳和雷焦艾米利亚大学）；USAL–Nanolab, Departamento de Física Fundamental, University of Salamanca（萨拉曼卡大学基础物理系USAL纳米实验室）；Istituto Italiano di Tecnologia（意大利理工学院）；Technological University Dublin（都柏林科技大学）；Institute Nanoscience, CNR（CNR纳米科学研究所）

Arslan Liaquat, Ghassem Baridi, Federico Rapuzzi, Daniele Goldoni, Vito Clerico, El Hadj Abidi, Yahya Moubarak Meziani, Mario Amado, Enrique Diez, Naveen Kumar,… 展开作者

Arslan Liaquat, Ghassem Baridi, Federico Rapuzzi, Daniele Goldoni, Vito Clerico, El Hadj Abidi, Yahya Moubarak Meziani, Mario Amado, Enrique Diez, Naveen Kumar, Camilia Coletti, Beatrice Cipriani, Hender Lopez, Giorgia Brancolini, Leonardo Martini, Luigi Rovati, Francesco Rossella

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AI总结：

研究利用基于石墨烯的电解质门控场效应晶体管，通过双电层高界面电容，将白蛋白吸附引起的静电扰动转化为电导调制，实现无标记实时定量检测人血清白蛋白，给出检测性能等贡献。

摘要：

准确检测人血清白蛋白（HSA）对肝肾疾病的早期诊断和监测至关重要。我们展示了一种基于石墨烯的电解质门控场效应晶体管（EGFET），用于在非法拉第操作下对HSA进行无标记实时定量。器件利用双电层的高界面电容将白蛋白吸附引起的静电扰动转化为可测量的电导调制。模拟等揭示相关机制，优化器件展现出检测限等性能，为蛋白质传感提供平台并洞察传输机制。

英文摘要：

Accurate detection of human serum albumin (HSA) is essential for the early diagnosis and monitoring of renal and hepatic disorders. We present a graphene-based electrolyte-gated field-effect transistor (EGFET) for label-free, real-time quantification of HSA under non-Faradaic operation. Devices exploit the high interfacial capacitance of the electric double layer (EDL) to transduce electrostatic perturbations induced by albumin adsorption into measurable conductance modulation. Negatively charged HSA molecules induce systematic modulation of the graphene channel, producing a concentration-dependent displacement of the Dirac voltage consistent with p-type doping. To establish a molecular-level interpretation of the sensing response, Brownian Dynamics simulations show that HSA adsorbs onto graphene through multiple adsorption orientations associated with heterogeneous interfacial charge distributions and variable dipole alignments relative to the surface. Adsorption is energetically stabilized by van der Waals interactions. Analysis of transfer characteristics across concentrations ranging from 0.01 to 30mgmL-1 reveals a correlation between surface charge density and carrier transport modulation within the electric double layer. Optimized devices exhibit a limit of detection of 0.0087 mg mL-1 and a linear dynamic range extending to 10 mg mL-1. The response remains non-Faradaic under sub-volt operation with reversible and reproducible behavior. The use of an inverse-mobility analytical metric highlights the role of disorder-enhanced carrier scattering in signal amplification, enabling sensitive electrostatic detection while preserving reversible device operation. These results establish liquid-gated graphene EGFETs as a promising platform for quantitative protein sensing and provide insight into disorder-mediated transport mechanisms in graphene bioelectronic devices.

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