脊髓刺激中的电场传播
Electric Field Propagation with Spinal Cord Stimulation
AI总结：
研究脊髓刺激中电场传播问题，结合组织物理特性及电磁等描述推导电场传输系数模型，用于计算不同脉宽下电场能量在目标神经组织的传输，助于优化脊髓刺激治疗。
AI中文摘要：
脊髓刺激常用于治疗慢性疼痛及研究瘫痪后运动恢复。目前大多知识依赖经验和半混合模型。利用组织物理特性及电磁等描述，推导脊髓中多层组织的电场传输系数，计算不同脉宽下电场能量在灰质或白质等目标神经组织的传输，揭示其与脉宽复杂关系及能量吸收情况，利于优化治疗。
英文摘要：
Spinal cord stimulation is routinely used for the treatment of chronic pain, and is increasingly being investigated for the restoration of movement after paralysis. However, most of our current knowledge on epidural spinal cord stimulation relies on empirical approaches and semi-hybrid models. Hence, optimizing this therapy requires a better theoretical understanding of how stimulation affects the target neural structures. Using the physical properties of tissues combined with an electromagnetic, dielectric, and metallic description of them, we derived the electric field transmission coefficient through a given number of layers of tissue in the spinal cord. We then used this model to calculate the transmission of electric field energy in target neural tissues such as grey or white matter for different pulse width. Simulations suggest that the propagation through the tissues of the spinal cord of an epidurally applied electric field has a complex relationship with the field pulse width. In addition the electric field energy is absorbed at the junction between dura matter and cerebrospinal fluid, and within the cerebrospinal fluid as induced current. These currents hit the different bodies floating within the cerebrospinal fluid, and/or dorsal horn in a very localized region of the spinal cord. The proposed models allow theoretical calculation of the transmission factor for different numbers of layers of tissue within the spinal canal, and for different electric field pulse widths. This eases the prediction of the expected energy reaching each layer of the spinal cord for different tissues, parameters, and electrode configurations, simplifying the optimization of spinal cord stimulation treatment.
