arXivDaily arXiv每日学术速递 周一至周五更新
​通知:联邦节假日调休:哥伦布日 / 原住民日(Columbus Day / Indigenous Peoples' Day),今日(13日)无更新。
arXiv 2606.10778cs.CV

从斑块到患者:数字病理学中斑块到全切片性能可迁移性的研究

From Patches to Patients: A study of the tile-to-slide performance transferability in Digital Pathology

Université Paris-Saclay, CentraleSupélec, Gustave Roussy, INSERM, IHU PRISM, Cancer Data Science Unit(巴黎-萨克雷大学、中央理工-高等电力学院、古斯塔夫·鲁西研究所、法国国家健康与医学研究院、IHU PRISM、癌症数据科学单元);Université Paris-Saclay, CentraleSupélec, MICS Laboratory(巴黎-萨克雷大学、中央理工-高等电力学院、MICS实验室)

Sofiène Boutaj, Leo Fillioux, Maria Vakalopoulou, Stergios Christodoulidis, Pierre Marza

AI总结:

研究斑块级线性探测能否作为全切片级性能的可靠代理,通过19个基础模型在42个切片级和16个斑块级任务上的基准测试,发现斑块与切片性能高度相关,斑块级基准测试可有效筛选候选模型。

摘要:

基础模型最近通过为全切片图像分析提供稳健表示,重新定义了组织病理学中的最先进技术。然而,为特定临床队列选择最优基础模型目前需要多个预处理步骤,随后对每个模型进行计算昂贵的特征提取和训练多实例学习聚合器。在这项工作中,我们研究高效的斑块级线性探测能否作为切片级性能的可靠代理,从而减少对每个候选编码器运行完整切片级管道的需求。我们在42个切片级和16个斑块级任务上对19个最先进的基础模型进行基准测试,使用ABMIL和均值池化聚合器比较斑块探测指标与切片级结果。我们观察到在不同任务难度下,斑块与切片性能之间存在高度相关性,表明编码器表示质量是WSI成功的主要决定因素。敏感性分析显示,可迁移性在不同模型间稳定,且受队列规模和每张切片斑块数量的影响大于平均任务难度。我们还测量了斑块级和切片级任务中最佳表现模型的一致性,表明斑块基准测试可靠地筛选出强候选模型。总体而言,我们的研究表明,斑块级基准测试为缩小候选模型范围提供了高效且实用的第一步,而切片级评估对于临床任务的最终验证仍然必不可少。

英文摘要:

Foundation Models (FMs) have recently redefined the state-of-the-art in histopathology by providing robust representations for whole-slide image (WSI) analysis. However, selecting the optimal foundation model (FM) for a specific clinical cohort currently requires multiple preprocessing steps, followed by computationally expensive feature extraction and the training of a Multiple Instance Learning (MIL) aggregator for every model. In this work, we investigate whether efficient tile-level linear probing can serve as a reliable proxy for slide-level performance, reducing the need to run full slide-level pipelines for every candidate encoder. We benchmark 19 state-of-the-art FMs on 42 slide-level and 16 tile-level tasks, comparing tile probing metrics against slide-level outcomes using ABMIL and Mean Pooling aggregations. We observe a high correlation between tile and slide performance across varying task difficulties, indicating that encoder representation quality is the primary determinant of WSI success. Sensitivity analyses show that transferability is stable across models and is more influenced by cohort sizes and numbers of tiles per slide than by average task difficulty. We also measure the agreement in best performing models between tile and slide-level tasks, showing tile benchmarks reliably shortlist strong candidates. Overall, our study indicates that tile-level benchmarking provides an efficient and practical first step for narrowing down candidate models, while slide-level evaluation remains essential for final validation on clinical tasks.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

↑