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arXiv 2603.22158cs.LGcs.AI

多模态生存分析与可本地部署的大语言模型

Multimodal Survival Analysis with Locally Deployable Large Language Models

University of Oxford(牛津大学)

Moritz Gögl, Christopher Yau

AI总结:

本文提出利用可本地部署的大语言模型进行多模态生存分析,结合临床文本、表格数据和基因组数据,通过教师-学生蒸馏和原理化的多模态融合,实现校准的生存概率估计和简洁的诊断文本生成,优于标准基线并在隐私和准确性方面表现更优。

摘要:

我们研究了整合临床文本、表格协变量和基因组资料的多模态生存分析,使用可本地部署的大语言模型(LLMs)。鉴于许多机构面临计算和隐私限制,这种设置推动了轻量级本地模型的应用。我们的方法通过教师-学生蒸馏和原理化的多模态融合,联合估计校准的生存概率并生成简洁且证据支持的预后文本。在TCGA队列中,它优于标准基线,避免了对云服务的依赖及相关的隐私问题,并降低了基础LLMs中可能出现的幻觉或校准不准确估计的风险。

英文摘要:

We study multimodal survival analysis integrating clinical text, tabular covariates, and genomic profiles using locally deployable large language models (LLMs). As many institutions face tight computational and privacy constraints, this setting motivates the use of lightweight, on-premises models. Our approach jointly estimates calibrated survival probabilities and generates concise, evidence-grounded prognosis text via teacher-student distillation and principled multimodal fusion. On a TCGA cohort, it outperforms standard baselines, avoids reliance on cloud services and associated privacy concerns, and reduces the risk of hallucinated or miscalibrated estimates that can be observed in base LLMs.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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