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arXiv 2511.12801cs.CV

通过用于MRI脑肿瘤分割统一模型的自评估深度学习模型增强神经肿瘤学诊疗能力

Enhancing Neuro-Oncology Through Self-Assessing Deep Learning Models for Brain Tumor Unified Model for MRI Segmentation

The Quarry Lane School(Quarry Lane 学校)

Andrew Zhou

AI总结:

针对脑肿瘤分割深度学习模型临床应用的缺陷,本研究提出带不确定性感知通道的改进nnUNet及结合正常/肿瘤数据的统一模型,可同时输出高精度分割结果与不确定性图,辅助临床手术决策。

摘要:

脑肿瘤的精准分割对诊断、手术规划与治疗监测至关重要。深度学习已在基准测试中取得进展,但两大问题限制其临床应用:一是无法对误差进行不确定性估计,二是无法分割肿瘤周边供手术参考的健康脑结构。现有方法未能将肿瘤定位与解剖背景相统一,且缺少置信度评分。本研究提出一种不确定性感知框架,为nnUNet增设体素级不确定性通道。该框架在BraTS2023数据集上训练,在不损害肿瘤分割精度的前提下,不确定性预测的相关系数达0.750,均方根偏差(RMSD)为0.047,可单次前向传播完成不确定性预测,无需额外网络或推理步骤,可辅助临床决策。针对全脑上下文,研究结合正常脑组织与肿瘤数据集构建统一模型,脑结构分割的戴斯相似性系数(DSC)达0.81,肿瘤分割DSC达0.86,关键区域分割性能稳健。结合两项创新,本研究首次实现可输出自然解剖环境下肿瘤分割结果及叠加不确定性图的模型。输出结果的可视化核验显示,不确定性可为预测结果评估、误差修正提供关键参考,助力AI辅助下的知情手术决策。

英文摘要:

Accurate segmentation of brain tumors is vital for diagnosis, surgical planning, and treatment monitoring. Deep learning has advanced on benchmarks, but two issues limit clinical use: no uncertainty estimates for errors and no segmentation of healthy brain structures around tumors for surgery. Current methods fail to unify tumor localization with anatomical context and lack confidence scores. This study presents an uncertainty-aware framework augmenting nnUNet with a channel for voxel-wise uncertainty. Trained on BraTS2023, it yields a correlation of 0.750 and RMSD of 0.047 for uncertainty without hurting tumor accuracy. It predicts uncertainty in one pass, with no extra networks or inferences, aiding clinical decisions. For whole-brain context, a unified model combines normal and cancer datasets, achieving a DSC of 0.81 for brain structures and 0.86 for tumor, with robust key-region performance. Combining both innovations gives the first model outputting tumor in natural surroundings plus an overlaid uncertainty map. Visual checks of outputs show uncertainty offers key insights to evaluate predictions and fix errors, helping informed surgical decisions from AI.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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