Radiology Report Generation (RRG) aims to automatically generate diagnostic reports from radiology images. To achieve this, existing methods have leveraged the powerful cross-modal generation capabilities of Multimodal Large Language Models (MLLMs), primarily focusing on optimizing cross-modal alignment between radiographs and reports through Supervised Fine-Tuning (SFT). However, by only performing instance-level alignment with the image-text pairs, the standard SFT paradigm fails to establish anatomically-grounded alignment, where the templated nature of reports often leads to sub-optimal generation quality. To address this, we propose \textsc{S2D-Align}, a novel SFT paradigm that establishes anatomically-grounded alignment by leveraging auxiliary signals of varying granularities. \textsc{S2D-Align} implements a shallow-to-deep strategy, progressively enriching the alignment process: it begins with the coarse radiograph-report pairing, then introduces reference reports for instance-level guidance, and ultimately utilizes key phrases to ground the generation in specific anatomical details. To bridge the different alignment stages, we introduce a memory-based adapter that empowers feature sharing, thereby integrating coarse and fine-grained guidance. For evaluation, we conduct experiments on the public \textsc{MIMIC-CXR} and \textsc{IU X-Ray} benchmarks, where \textsc{S2D-Align} achieves state-of-the-art performance compared to existing methods. Ablation studies validate the effectiveness of our multi-stage, auxiliary-guided approach, highlighting a promising direction for enhancing grounding capabilities in complex, multi-modal generation tasks.
Faculty of Medicine, American University of Beirut(贝鲁特美国大学医学院);American University of Beirut Medical Center(贝鲁特美国大学医学中心);Department of Diagnostic Radiology, American University of Beirut Medical Center(贝鲁特美国大学医学中心诊断放射科)
During their formative years, radiology trainees are required to interpret hundreds of mammograms per month, with the objective of becoming apt at discerning the subtle patterns differentiating benign from malignant lesions. Unfortunately, medico-legal and technical hurdles make it difficult to access and query medical images for training. In this paper we train a generative adversarial network (GAN) to synthesize 512 x 512 high-resolution mammograms. The resulting model leads to the unsupervised separation of high-level features (e.g. the standard mammography views and the nature of the breas…
SGRNet: Spatially Guided Radiology Network for Structured Radiological Reporting of Head and Neck Cancer
University of Strasbourg(斯特拉斯堡大学);IHU Strasbourg(斯特拉斯堡大学医院研究所);Indian Institute of Technology (IIT) Madras(印度马德拉斯理工学院);All India Institute of Medical Sciences(全印度医学科学院)
TRACE: Temporally Reliable Anatomically-Conditioned 3D CT Generation with Enhanced Efficiency
Department of Computer Science, Durham University(杜伦大学计算机科学系);Department of Automation, Tsinghua University(清华大学自动化系);College of Computer Science and Engineering, Dalian Minzu University(大连民族大学计算机科学与工程学院);Department of Engineering Science, University of Oxford(牛津大学工程科学系);Jarvis Research Center, Tencent YouTu Lab(腾讯YouTu实验室 Jarvis 研究中心);School of Engineering Mathematics and Technology, University of Bristol(布里斯托大学工程数学与技术学院);Medical Artificial Intelligence Laboratory, School of Engineering, Westlake University(西湖大学工程学院医学人工智能实验室)
Anatomy-aware Fine-grained Multimodal Fusion for Laryngopharyngeal Cancer T-Staging Prediction Using CT and Radiology Report
DAMO Academy, Alibaba Group(阿里巴巴集团达摩院);Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College(中国医学科学院北京协和医学院北京协和医院);Hupan Laboratory(湖畔实验室);Fuzhou University(福州大学);Eye & ENT Hospital, Fudan University(复旦大学附属眼耳鼻喉科医院);Zhongshan Hospital, Fudan University(复旦大学附属中山医院);Chang Gung Memorial Hospital(长庚纪念医院);Zhongshan Hospital(Xiamen), Fudan University(复旦大学附属中山医院厦门医院)
Despite its tremendous value for the diagnosis, treatment monitoring and surveillance of children with cancer, whole body staging with positron emission tomography (PET) is time consuming and associated with considerable radiation exposure. 100x (1% of the standard clinical dosage) ultra-low-dose/ultra-fast whole-body PET reconstruction has the potential for cancer imaging with unprecedented speed and improved safety, but it cannot be achieved by the naive use of machine learning techniques. In this study, we utilize the global similarity between baseline and follow-up PET and magnetic resonan…
MedSyn2: Flexible Control of 3D CT Generation via Text and Semantically-Defined Segmentation Prompts
Boston University School of Engineering(波士顿大学工程学院);Stanford University(斯坦福大学);University of Pittsburgh Medical Center(匹兹堡大学医学中心);Boston University School of Medicine(波士顿大学医学院)
ASAP: Advancing Medical Volumetric Representation Learning with Anatomy-aware Semantically-adaptive Pre-training
School of Biomedical Engineering, Division of Life Sciences and Medicine, University of Science and Technology of China(生物医学工程学院,生命科学与医学系,中国科学技术大学);Medical Imaging, Robotics, Analytic Computing & Learning (MIRACLE) Lab, YRD-RIGHT, USTC Suzhou Institute for Advanced Research(医学影像、机器人、分析计算与学习(MIRACLE)实验室,YRD-RIGHT,中国科学技术大学苏州研究院);Jiangsu Provincial Key Laboratory of Multimodal Digital Twin Technology(江苏省多模态数字孪生技术重点实验室);Biomedical Basic Research Center (BBRC) of Jiangsu Province(江苏省生物医学基础研究中心);Department of Radiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, USTC(放射科,中国科学技术大学第一附属医院,生命科学与医学系,中国科学技术大学);Anhui IFLYTEK CO., Ltd(安徽科大讯飞股份有限公司);School of Medicine, Stanford University(医学院,斯坦福大学);State Key Laboratory of Precision and Intelligent Chemistry, Hefei, Anhui, China(安徽省精密与智能化学重点实验室,合肥,安徽,中国)
Mass General Brigham(麻省总医院布里格姆医疗系统);Harvard Medical School(哈佛医学院);Maastricht University(马斯特里赫特大学);Dana-Farber Cancer Institute(丹娜法伯癌症研究院);Technical University of Munich(慕尼黑工业大学);German Heart Center(德国心脏中心)
Detection and Localization of Subdural Hematoma Using Deep Learning on Computed Tomography
Operations Research Center, Massachusetts Institute of Technology(麻省理工学院运营研究中心);Boston University(波士顿大学);Massachusetts Institute of Technology(麻省理工学院);University of Connecticut School of Medicine(康奈尔大学医学学院);Hartford HealthCare(哈特福德医疗集团);Sloan School of Management, Massachusetts Institute of Technology(麻省理工学院斯隆管理学院)
Arizona State University(亚利桑那州立大学);Mayo Clinic(梅奥诊所)
Training a deep convolutional neural network (CNN) from scratch is difficult because it requires a large amount of labeled training data and a great deal of expertise to ensure proper convergence. A promising alternative is to fine-tune a CNN that has been pre-trained using, for instance, a large set of labeled natural images. However, the substantial differences between natural and medical images may advise against such knowledge transfer. In this paper, we seek to answer the following central question in the context of medical image analysis: \emph{Can the use of pre-trained deep CNNs with s…
Deep Learning Predicts Mammographic Breast Density in Clinical Breast Ultrasound Images
University of Hawai’i at Mānoa(夏威夷大学马诺阿分校);University of Hawai’i Cancer Center(夏威夷大学癌症中心);The Queen’s Medical Center(皇后医疗中心);Hawaiʻi Pacific Health(夏威夷太平洋健康);Hawaiʻi Diagnostic Radiology Services(夏威夷诊断放射服务中心)
McGovern Institute for Brain Research, MIT(麻省理工学院麦戈文脑研究所);KU Leuven(鲁汶大学);Bay Labs Inc.(Bay Labs公司);New York University(纽约大学);Columbia University(哥伦比亚大学);Stanford University(斯坦福大学)
Deep convolutional artificial neural networks (ANNs) are the leading class of candidate models of the mechanisms of visual processing in the primate ventral stream. While initially inspired by brain anatomy, over the past years, these ANNs have evolved from a simple eight-layer architecture in AlexNet to extremely deep and branching architectures, demonstrating increasingly better object categorization performance, yet bringing into question how brain-like they still are. In particular, typical deep models from the machine learning community are often hard to map onto the brain's anatomy due t…