一种硫化铜-羟丙基β-环糊精-还原氧化石墨烯复合材料用于生物样品中5-羟色胺的高灵敏电化学检测
A copper sulfide-hydroxypropyl $β$-Cyclodextrin-reduced graphene oxide composite for highly sensitive electrochemical detection of 5-hydroxytryptamine in biological samples
AI总结：
本文提出一种Cu2S/Hβcd-rGO复合电催化剂，用于生物样品中5-羟色胺的高灵敏电化学检测，具有宽线性范围、低检测限和优异选择性。
摘要：
神经递质的精确识别对于理解脑功能、检测神经系统疾病以及制定成功的治疗策略至关重要。本工作研究了利用优异的杂化电催化剂Cu2S/Hβcd-rGO对血清素（5-羟色胺，SR）进行电化学检测。Cu2S具有改进的催化活性和增强的电荷转移等显著特性，当其与Hβcd-rGO复合时，将进一步提升性能。Cu2S与Hβcd-rGO的整合受范德华力和静电相互作用调控，使其成为一种稳定的催化剂，且不破坏复合结构。同时，Cu2S/Hβcd与rGO层状片之间的团聚可被大幅减少，从而改善导电性。因此，上述特性在将其制备于玻碳电极（GCE）上时，带来了改善的氧化响应电流。该传感器在0.019至0.299 μM和4.28至403.14 μM的宽线性范围内表现出灵敏响应，检测限（LOD）低至1.2 nM（即0.0012 μM），灵敏度约为15.9 μA μM⁻¹ cm⁻²。该传感器对常见干扰物（包括氨基苯酚、多巴胺、肾上腺素、对苯二酚、褪黑素和氯）表现出优异的选择性。在生物样品中的实际样品研究显示出良好的回收率，证明了所制备传感器的有效性。因此，Cu2S/Hβcd-rGO这种成本低廉且简便的集成方式将成为检测血清素的杰出电催化剂。
英文摘要：
The precise identification of neurotransmitters is essential for comprehending cerebral function, detecting neurological conditions, and formulating successful therapeutic approaches. The present work investigates the electrochemical detection of serotonin with the excellent hybrid electrocatalyst $Cu_2S/Hβcd-rGO$. $Cu_2S$, with its significant features as improved catalytic activity and enhanced charge transfer when combined with $Hβcd-rGO$, will enhance the performance. The integration of $Cu_2S$ with $Hβcd-rGO$, regulated by the van der Waals force and the electrostatic interaction, makes it a stable catalyst without disrupting the composite structure. Also, the aggregation of the $Cu_2S/Hβcd$ with the layered sheets of rGO can be highly reduced and resulting in the improvement of the conductivity. Thus, the above features resulted in the improved oxidation response current when fabricated over the glassy carbon electrode (GCE). The SR showed sensitive response at a broad linear range of 0.019 to 0.299 $μ$M and 4.28 to 403.14 $μ$M, resulting in a lower limit of detection (LOD) of 1.2 nM or 0.0012 $μ$M and a sensitivity of about 15.9 $μ$A $μM^{-1}$ $cm^{-2}$. The sensor demonstrated excellent selectivity against common interferents, including aminophenol, dopamine, epinephrine, hydroquinone, melatonin, and chlorine. The real sample studies in the biological samples show good recovery values, showing the effectiveness of the as-fabricated sensor. Thus, the cost-efficient and straightforward integration of $Cu_2S/Hβcd-rGO$ will be an outstanding electrocatalyst for detecting SR.
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