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arXiv 2511.01275cs.LGcs.AI

对抗性时空注意网络用于癫痫发作预测

Adversarial Spatio-Temporal Attention Networks for Epileptic Seizure Forecasting

Zan Li, Kyongmin Yeo, Wesley Gifford, Lara Marcuse, Madeline Fields, Bülent Yener

AI总结:

STAN通过对抗性时空注意网络实现癫痫发作预测,具有高灵敏度和低误报率,适用于实时边缘部署。

摘要:

从多变量EEG信号预测癫痫发作代表医疗时间序列预测中的关键挑战,需要高灵敏度、低误报率和个体适应性。我们提出了STAN,一种对抗性时空注意网络,通过交替的空间和时间模块的级联注意块,联合建模大脑连接和神经动态。与现有方法假设固定预发作持续时间或分别处理空间和时间特征不同,STAN通过统一的级联架构捕捉空间和时间模式之间的双向依赖关系。对抗训练与梯度惩罚使模型能够通过明确定义的15分钟预发作窗口学习区分发作间和发作前状态。连续90分钟预发作监测显示,所学的空间时间注意模式实现了早期检测:可靠警报在个体特定时间(通常在发作前15-45分钟)触发,反映了模型捕捉细微预发作动态的能力,而无需个性化训练。在两个基准EEG数据集(CHB-MIT头皮:8个受试者,46个事件;MSSM脑内:4个受试者,14个事件)上的实验表明,STAN达到了最先进的性能:96.6%的灵敏度,每小时0.011次误报,以及94.2%的灵敏度,每小时0.063次误报,同时保持计算效率(230万参数,45毫秒延迟,180MB内存),适用于实时边缘部署。除了癫痫之外,所提出的框架为医疗和其他时间序列领域中需要个体异质性和可解释性的时空预测提供了通用范式。

英文摘要:

Forecasting epileptic seizures from multivariate EEG signals represents a critical challenge in healthcare time series prediction, requiring high sensitivity, low false alarm rates, and subject-specific adaptability. We present STAN, an Adversarial Spatio-Temporal Attention Network that jointly models spatial brain connectivity and temporal neural dynamics through cascaded attention blocks with alternating spatial and temporal modules. Unlike existing approaches that assume fixed preictal durations or separately process spatial and temporal features, STAN captures bidirectional dependencies between spatial and temporal patterns through a unified cascaded architecture. Adversarial training with gradient penalty enables robust discrimination between interictal and preictal states learned from clearly defined 15-minute preictal windows. Continuous 90-minute pre-seizure monitoring reveals that the learned spatio-temporal attention patterns enable early detection: reliable alarms trigger at subject-specific times (typically 15-45 minutes before onset), reflecting the model's capacity to capture subtle preictal dynamics without requiring individualized training. Experiments on two benchmark EEG datasets (CHB-MIT scalp: 8 subjects, 46 events; MSSM intracranial: 4 subjects, 14 events) demonstrate state-of-the-art performance: 96.6% sensitivity with 0.011 false detections per hour and 94.2% sensitivity with 0.063 false detections per hour, respectively, while maintaining computational efficiency (2.3M parameters, 45 ms latency, 180 MB memory) for real-time edge deployment. Beyond epilepsy, the proposed framework provides a general paradigm for spatio-temporal forecasting in healthcare and other time series domains where individual heterogeneity and interpretability are crucial.

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