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arXiv 2510.24136eess.IVcs.CV
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MSRANetV2: 一种用于结直肠组织病理图像多分类的可解释深度学习架构

MSRANetV2: An Explainable Deep Learning Architecture for Multi-class Classification of Colorectal Histopathological Images

Rajshahi University of Engineering & Technology(拉杰沙希工程技术大学);Qatar University(卡塔尔大学)

Ovi Sarkar, Md Shafiuzzaman, Md. Faysal Ahamed, Golam Mahmud, Muhammad E. H. Chowdhury

AI总结:

本研究针对结直肠癌组织病理图像分类,提出融合残差注意力与SE模块的MSRANetV2架构,在两个公开数据集上取得优异性能,并通过Grad-CAM提升模型可解释性。

摘要:

结直肠癌(CRC)是全球癌症相关死亡的主要原因之一,及时精准的检测对改善患者预后至关重要。结肠镜检查和组织学检查等传统诊断方法通常存在主观性,极其耗时且易受个体差异影响。随着数字病理学的发展,深度学习算法已成为提升诊断精准度与效率的有力手段。在本研究中,我们提出了一种名为MSRANetV2的卷积神经网络架构,专门针对结直肠组织图像分类进行了优化。该模型采用ResNet50V2作为骨干网络,辅以残差注意力机制和压缩-激励(squeeze-and-excitation, SE)模块,以提取深层语义特征和细粒度空间特征。通过通道对齐和上采样操作,MSRANetV2能够有效融合多尺度表征,从而提升分类的鲁棒性。我们在两个公开数据集CRC-VAL-HE-7K和NCT-CRC-HE-100K上采用五折分层交叉验证策略对模型进行评估。所提模型在7K数据集上的平均精确率、召回率、F1分数、AUC和测试准确率分别达到0.9884±0.0151、0.9900±0.0151、0.9900±0.0145、0.9999±0.00006和0.9905±0.0025;在100K数据集上则分别为0.9904±0.0091、0.9900±0.0071、0.9900±0.0071、0.9997±0.00016和0.9902±0.0006。此外,我们引入了Grad-CAM可视化方法,通过高亮医学相关的组织区域来增强模型的可解释性。这些结果证实,MSRANetV2是一种用于结直肠癌组织分类的可靠、可解释且高性能的架构模型。

英文摘要:

Colorectal cancer (CRC) is a leading worldwide cause of cancer-related mortality, and the role of prompt precise detection is of paramount interest in improving patient outcomes. Conventional diagnostic methods such as colonoscopy and histological examination routinely exhibit subjectivity, are extremely time-consuming, and are susceptible to variation. Through the development of digital pathology, deep learning algorithms have become a powerful approach in enhancing diagnostic precision and efficiency. In our work, we proposed a convolutional neural network architecture named MSRANetV2, specially optimized for the classification of colorectal tissue images. The model employs a ResNet50V2 backbone, extended with residual attention mechanisms and squeeze-and-excitation (SE) blocks, to extract deep semantic and fine-grained spatial features. With channel alignment and upsampling operations, MSRANetV2 effectively fuses multi-scale representations, thereby enhancing the robustness of the classification. We evaluated our model on a five-fold stratified cross-validation strategy on two publicly available datasets: CRC-VAL-HE-7K and NCT-CRC-HE-100K. The proposed model achieved remarkable average Precision, recall, F1-score, AUC, and test accuracy were 0.9884 plus-minus 0.0151, 0.9900 plus-minus 0.0151, 0.9900 plus-minus 0.0145, 0.9999 plus-minus 0.00006, and 0.9905 plus-minus 0.0025 on the 7K dataset. On the 100K dataset, they were 0.9904 plus-minus 0.0091, 0.9900 plus-minus 0.0071, 0.9900 plus-minus 0.0071, 0.9997 plus-minus 0.00016, and 0.9902 plus-minus 0.0006. Additionally, Grad-CAM visualizations were incorporated to enhance model interpretability by highlighting tissue areas that are medically relevant. These findings validate that MSRANetV2 is a reliable, interpretable, and high-performing architectural model for classifying CRC tissues.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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