采用多光谱显微镜的注射用奎宁质量保证控制新方法
New Method for Injectable Quinine Quality Assurance Control Using a Multi-Spectral Microscope
AI总结：
针对非洲无质量保证的抗疟药泛滥问题，本研究提出利用配备紫外-可见光激光器的定制多光谱显微镜，通过光强直方图面积校准曲线检测注射用奎宁合规性，为常规药品质量控制提供新方案。
摘要：
非洲是全球受疟疾影响最严重的地区。在现有治疗方案中，注射用奎宁被视为有效的抗疟药物之一，但无质量保证的抗疟药显然已在非洲各地市场大量流通。为解决这一问题，建立用于抗疟药质量控制的定量与定性分析体系变得愈发必要。本研究的目标是尝试将配备紫外-可见光激光器的定制化多光谱显微镜，用于注射用奎宁的常规质量保证控制。为此，我们构建了奎宁溶液浓度与穿过溶液的光强直方图下面积的函数关系校准曲线。借助该校准曲线，我们可依据相关药典检测任意注射用奎宁的合规性。该技术是一种颇具前景的常规药品质量控制替代方案。
英文摘要：
Africa is the world region that is most affected by malaria. Among the therapies used, injectable quinine is considered to be one of the effective antimalarial drug, however non-quality assured antimalarials clearly have a strong market penetration across Africa. To overcome this problem, it becomes more and more necessary to set up quantitative and qualitative analysis system for antimalarial quality control. The objective of the present investigation is an attempt to use customized multispectral microscope equipped with UV-Visible lasers for injectable quinine quality assurance control routinely. For that, we have established the calibration curve of quinine solution concentration as a function of area under light intensity histogram crossing the solution. From this calibration curve, we can check the conformity of any injectable quinine according to the pharmacopoeia involved. The proposed technique is a promising alternative for drug quality control routinely.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
