集体不同：信息交流与速度-准确性权衡在自组织图案化中的作用
Collective is different: Information exchange and speed-accuracy trade-offs in self-organized patterning
AI总结：
本文提出一个细胞图案化模型，揭示集体决策中速度与准确性之间的权衡，以及细胞间信息流动的非单调特性。
摘要：
在发育过程中，高度有序的结构通过细胞集体协调形成。尽管最近的进展已经阐明了单个细胞如何处理和响应外部信号，但理解集体细胞决策仍然是一个重大挑战。在此，我们引入了一个最小、可分析的模型，通过局部细胞-细胞交流来模拟细胞图案化。利用这一框架，我们识别了集体图案形成中速度与准确性之间的权衡，并通过适应随机化学动力学技术，量化了图案化过程中细胞间的信信息流动。我们的分析揭示了集体图案化的一些反直觉特征：全局优化的解决方案不一定最大化细胞间的信息传输，单个细胞在孤立状态下可能显得次优。此外，模型预测在图案化过程中，细胞间即时信息共享的时间非单调。对最近果蝇蛹腹部侧抑制实验数据的分析发现，存在类似的效果。
英文摘要：
During development, highly ordered structures emerge as cells collectively coordinate with each other. While recent advances have clarified how individual cells process and respond to external signals, understanding collective cellular decision making remains a major challenge. Here, we introduce a minimal, analytically tractable, model of cell patterning via local cell-cell communication. Using this framework, we identify a trade-off between the speed and accuracy of collective pattern formation and, by adapting techniques from stochastic chemical kinetics, quantify how information flows between cells during patterning. Our analysis reveals counterintuitive features of collective patterning: globally optimized solutions do not necessarily maximize intercellular information transfer and individual cells may appear suboptimal in isolation. Moreover, the model predicts that instantaneous information shared between cells can be non-monotonic in time as patterning occurs. An analysis of recent experimental data from lateral inhibition in Drosophila pupal abdomen finds a qualitatively similar effect.
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