解码MGMT甲基化：迈向胶质母细胞瘤精准医疗的一步

Prediction of MGMT Methylation Status of Glioblastoma using Radiomics and Latent Space Shape Features

In this paper we propose a method for predicting the status of MGMT promoter methylation in high-grade gliomas. From the available MR images, we segment the tumor using deep convolutional neural networks and extract both radiomic features and shape features learned by a variational autoencoder. We implemented a standard machine learning workflow to obtain predictions, consisting of feature selection followed by training of a random forest classification model. We trained and evaluated our method on the RSNA-ASNR-MICCAI BraTS 2021 challenge dataset and submitted our predictions to the challenge…

Novel Local Radiomic Bayesian Classifiers for Non-Invasive Prediction of MGMT Methylation Status in Glioblastoma

Glioblastoma, an aggressive brain cancer, is amongst the most lethal of all cancers. Expression of the O6-methylguanine-DNA-methyltransferase (MGMT) gene in glioblastoma tumor tissue is of clinical importance as it has a significant effect on the efficacy of Temozolomide, the primary chemotherapy treatment administered to glioblastoma patients. Currently, MGMT methylation is determined through an invasive brain biopsy and subsequent genetic analysis of the extracted tumor tissue. In this work, we present novel Bayesian classifiers that make probabilistic predictions of MGMT methylation status …

Is it Possible to Predict MGMT Promoter Methylation from Brain Tumor MRI Scans using Deep Learning Models?

Glioblastoma is a common brain malignancy that tends to occur in older adults and is almost always lethal. The effectiveness of chemotherapy, being the standard treatment for most cancer types, can be improved if a particular genetic sequence in the tumor known as MGMT promoter is methylated. However, to identify the state of the MGMT promoter, the conventional approach is to perform a biopsy for genetic analysis, which is time and effort consuming. A couple of recent publications proposed a connection between the MGMT promoter state and the MRI scans of the tumor and hence suggested the use o…

使用MRI扫描预测MGMT启动子甲基化状态？对深度学习模型的广泛实验评估

MGMT promoter methylation status prediction using MRI scans? An extensive experimental evaluation of deep learning models

本研究利用深度学习模型和包含585名参与者的公开MRI数据集预测胶质母细胞瘤的MGMT启动子甲基化状态，通过多种可视化方法测试发现模型性能与预期无相关性，强调需外部队列数据验证以确保诊断可靠性。

Optimizing Prediction of MGMT Promoter Methylation from MRI Scans using Adversarial Learning

Glioblastoma Multiforme (GBM) is a malignant brain cancer forming around 48% of al brain and Central Nervous System (CNS) cancers. It is estimated that annually over 13,000 deaths occur in the US due to GBM, making it crucial to have early diagnosis systems that can lead to predictable and effective treatment. The most common treatment after GBM diagnosis is chemotherapy, which works by sending rapidly dividing cells to apoptosis. However, this form of treatment is not effective when the MGMT promoter sequence is methylated, and instead leads to severe side effects decreasing patient survivabi…

Artificial Intelligence Solution for Effective Treatment Planning for Glioblastoma Patients

Glioblastomas are the most common malignant brain tumors in adults. Approximately 200000 people die each year from Glioblastoma in the world. Glioblastoma patients have a median survival of 12 months with optimal therapy and about 4 months without treatment. Glioblastomas appear as heterogeneous necrotic masses with irregular peripheral enhancement, surrounded by vasogenic edema. The current standard of care includes surgical resection, radiotherapy and chemotherapy, which require accurate segmentation of brain tumor subregions. For effective treatment planning, it is vital to identify the met…