肺静脉隔离的脉冲电场消融计算建模
Computational modeling of Pulsed Field Ablation for pulmonary vein isolation
AI总结：
本研究提出并验证了一个患者特异性的3D计算框架，用于模拟脉冲电场消融在肺静脉隔离中的效果，定量评估了不同导管的损伤表现，为导管设计和治疗规划提供了基础。
摘要：
脉冲电场消融（PFA）已成为治疗心房颤动（AF）的传统热消融技术的非热替代方案。本研究提出了一个患者特异性的3D计算框架，用于建模PFA对肺静脉隔离（PVI）的影响。该建模框架经过已发表的数值和实验数据的严格验证，在多种场景下表现出高度一致性。利用真实的左心房（LA）解剖结构，模拟了市售的环形、花形和篮式导管配置，以评估不同施加电压下的损伤形成。使用包括损伤体积、能量递送效率和透壁性在内的多种指标，对每种导管的性能进行了定量评估。模拟结果表明，环形导管在较低电压下提供最高的能量递送效率和目标覆盖范围，而篮式导管产生最大的损伤体积。该框架为探索PFA应用中的导管设计和治疗规划提供了有用的基础。
英文摘要：
Pulsed field ablation (PFA) has emerged as a non-thermal alternative to traditional thermal ablation techniques for the treatment of atrial fibrillation (AF). This study presents a patient-specific 3D computational framework to model the effects of PFA on pulmonary vein isolation (PVI). The modeling framework is rigorously validated against published numerical and experimental data, demonstrating strong agreement across a range of scenarios. Using realistic left atrial (LA) anatomy, commercially available circular, flower, and basket catheter configurations are simulated to evaluate lesion formation across different applied voltages. The performance of each catheter type is quantitatively assessed using multiple metrics, including lesion volume, energy delivery efficiency and transmurality. Simulation results show that circular catheters provide the highest energy delivery efficiency and target coverage at lower voltages, while basket catheters produce the largest lesion volumes. This framework offers a useful basis for exploring catheter design and treatment planning in PFA applications.
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