细胞力学、环境几何与细胞极性调控细胞-细胞碰撞结果
Cell mechanics, environmental geometry, and cell polarity control cell-cell collision outcomes
AI总结：
本研究通过相场模型和线性稳定性分析，发现细胞可变形性、极化正反馈强度及纤维间距共同调控纤维几何中细胞碰撞时擦肩而过的概率。
摘要：
爬行细胞之间的相互作用对许多生物过程至关重要，可通过测量细胞-细胞碰撞进行量化。传统上，细胞-细胞碰撞实验在二维平坦基底上进行，碰撞细胞在接触后会发生再极化并相互远离，这一现象被称为“接触性运动抑制”（CIL）。受近期实验启发——这些实验表明，悬浮在纳米纤维上的细胞其CIL行为与平坦基底上的细胞有本质不同——我们开发了一个用于纤维几何中细胞运动和双细胞碰撞的相场模型。我们的模型包含细胞-细胞和细胞-纤维粘附，以及一个简单的细胞极性正反馈机制。我们聚焦于两条平行纤维上的细胞碰撞，发现更大的细胞可变形性（更低的膜张力）、更强的极化正反馈以及更大的纤维间距会促进更多细胞相互擦肩而过的发生。我们能够利用碰撞时细胞-细胞界面上的简单线性稳定性分析来捕捉这一行为。
英文摘要：
Interactions between crawling cells, which are essential for many biological processes, can be quantified by measuring cell-cell collisions. Conventionally, experiments of cell-cell collisions are conducted on two-dimensional flat substrates, where colliding cells repolarize and move away upon contact with one another in "contact inhibition of locomotion" (CIL). Inspired by recent experiments that show cells on suspended nanofibers have qualitatively different CIL behaviors than those on flat substrates, we develop a phase field model of cell motility and two-cell collisions in fiber geometries. Our model includes cell-cell and cell-fiber adhesion, and a simple positive feedback mechanism of cell polarity. We focus on cell collisions on two parallel fibers, finding that larger cell deformability (lower membrane tension), larger positive feedback of polarization, and larger fiber spacing promote more occurrences of cells walking past one another. We can capture this behavior using a simple linear stability analysis on the cell-cell interface upon collision.
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