arXivDaily arXiv每日学术速递 周一至周五更新
arXiv 2502.09656q-bio.QMcs.CVeess.IV
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采用软标签的多组学融合以增强鼻咽癌患者放疗后远处转移预测

Multi-Omics Fusion with Soft Labeling for Enhanced Prediction of Distant Metastasis in Nasopharyngeal Carcinoma Patients after Radiotherapy

The Hong Kong Polytechnic University(香港理工大学);Research Institute for Smart Ageing, The Hong Kong Polytechnic University(香港理工大学智能老龄化研究院)

Jiabao Sheng, SaiKit Lam, Jiang Zhang, Yuanpeng Zhang, Jing Cai

AI总结:

针对多源组学与影像设备差异及标签拟合僵化问题,提出结合软标签的多核晚期融合方法,并在 NPC-ContraParotid 数据集上验证其放疗后远处转移预测的鲁棒性与有效性。

摘要:

组学融合已成为医学图像处理领域的一种关键预处理方法,为多项研究提供了重要帮助。组学数据整合过程中遇到的挑战之一,是数据源和医学成像设备差异所导致的不可预测性。为克服这一挑战,并促进其联合应用于特定医学目标,本研究旨在开发一种融合方法,以缓解组学数据中固有的差异。多核晚期融合方法作为应对这一特定挑战的有效策略,已得到广泛应用。通过使用合适的单核函数映射内在特征,并随后在高维空间中对其进行合并,可以获得高效的数据表示。该方法有效解决了前述差异。标签拟合的不灵活性限制了多核晚期融合方法在复杂鼻咽癌(NPC)数据集上的使用,从而影响通用分类器处理高维特征的效果。这一创新方法旨在增大两个队列之间的差异,从而为标签分配提供更灵活的结构。对 NPC-ContraParotid 数据集的检验证明了该模型的鲁棒性和有效性,表明其有潜力成为预测鼻咽癌(NPC)患者远处转移的有价值工具。

英文摘要:

Omics fusion has emerged as a crucial preprocessing approach in the field of medical image processing, providing significant assistance to several studies. One of the challenges encountered in the integration of omics data is the presence of unpredictability arising from disparities in data sources and medical imaging equipment. In order to overcome this challenge and facilitate the integration of their joint application to specific medical objectives, this study aims to develop a fusion methodology that mitigates the disparities inherent in omics data. The utilization of the multi-kernel late-fusion method has gained significant popularity as an effective strategy for addressing this particular challenge. An efficient representation of the data may be achieved by utilizing a suitable single-kernel function to map the inherent features and afterward merging them in a space with a high number of dimensions. This approach effectively addresses the differences noted before. The inflexibility of label fitting poses a constraint on the use of multi-kernel late-fusion methods in complex nasopharyngeal carcinoma (NPC) datasets, hence affecting the efficacy of general classifiers in dealing with high-dimensional characteristics. This innovative methodology aims to increase the disparity between the two cohorts, hence providing a more flexible structure for the allocation of labels. The examination of the NPC-ContraParotid dataset demonstrates the model's robustness and efficacy, indicating its potential as a valuable tool for predicting distant metastases in patients with nasopharyngeal carcinoma (NPC).

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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