通过阻断颞浅动脉评估激光散斑成像中脑血流与头皮血流的敏感性
Assessing Sensitivity of Brain-to-Scalp Blood Flows in Laser Speckle Imaging by Occluding the Superficial Temporal Artery
AI总结：
本研究开发七通道散斑对比度光谱系统，通过阻断颞浅动脉分离头皮与脑血流信号，证实了系统对脑血流的敏感性并得出最佳探测配置。
摘要：
脑血流是脑血管监测的关键指标，应用于中风检测、脑损伤评估、衰老及神经系统疾病。由于头皮和颅骨阻碍了对大脑的直接接触，且其自身包含必须被分离的血流动力学，因此无创测量脑血流动力学具有挑战性。我们开发了一套聚合式七通道散斑对比度光谱系统，以无创方式测量血流和血容量。每个通道具有不同的源探距，针对不同深度，以分别检测头皮和脑血流动力学。通过短暂阻断仅向头皮供血的颞浅动脉，我们将表面血流动力学与脑信号分离。对20名受试者的结果显示，对头皮敏感的通道在阻断期间血流动力学显著降低，而对脑敏感的通道变化极小。这为光学测量中脑-头皮敏感性提供了实验证据，突出了无创优先探测脑信号的最佳配置。
英文摘要：
Cerebral blood flow is a critical metric for cerebrovascular monitoring, with applications in stroke detection, brain injury evaluation, aging, and neurological disorders. Non-invasively measuring cerebral blood dynamics is challenging due to the scalp and skull, which obstruct direct brain access and contain their own blood dynamics that must be isolated. We developed an aggregated seven-channel speckle contrast optical spectroscopy system to measure blood flow and blood volume non-invasively. Each channel, with distinct source-to-detector distance, targeted different depths to detect scalp and brain blood dynamics separately. By briefly occluding the superficial temporal artery, which supplies blood only to the scalp, we isolated surface blood dynamics from brain signals. Results on 20 subjects show that scalp-sensitive channels experienced significant reductions in blood dynamics during occlusion, while brain-sensitive channels experienced minimal changes. This provides experimental evidence of brain-to-scalp sensitivity in optical measurements, highlighting optimal configuration for preferentially probing brain signals non-invasively.
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