一次性光声窗口实现经济高效的光声-超声双模态成像
Disposable Opto-Acoustic Window Enabled Cost-effective Photoacoustic-Ultrasound Dual-modal Imaging
AI总结：
本文提出一种带一次性光声窗口的同轴光声-超声双模态成像系统，通过单次激光脉冲同时产生光声和超声信号，实现双模态成像，分辨率达215微米和91.125微米，信噪比分别达37.48分贝和29.75分贝，为现有光声系统低成本扩展超声功能提供了方案。
摘要：
光声成像（PAI）和超声成像（USI）是重要的生物医学成像技术，因其在组织结构与功能可视化方面具有独特且互补的优势。在本快报中，我们提出了一种带有一次性光声窗口的同轴光声-超声双模态成像系统（coPAUS）。该光声窗口允许部分光透过，另一部分光则通过光声效应转换为超声传输信号。通过单次激光脉冲照射，可同时产生光声信号和反射超声信号。随后，线性阵列探头接收光声和超声信号，实现同步的双模态光声和超声成像。我们进行了离体实验，涉及铅笔芯、毛发和带黑点的塑料管，以及人体手指的在体实验。该系统在光声和超声成像的分辨率分别为215微米和91.125微米，光声和超声信号的信噪比分别高达37.48分贝和29.75分贝，证明了coPAUS双模态成像的可行性。所提出的带有一次性光声窗口的coPAUS系统，为基于现有光声成像系统实现超声成像能力提供了一种即时且经济高效的方法。
英文摘要：
Photoacoustic imaging (PAI) and ultrasound imaging (USI) are important biomedical imaging techniques, due to their unique and complementary advantages in tissue's structure and function visualization. In this Letter, we proposed a coaxial photoacoustic-ultrasound dual-modal imaging system (coPAUS) with disposable opto-acoustic window. This opto-acoustic window allows part of light to go through it, and another part of light to be converted to ultrasound transmission signal by photoacoustic effect. By single laser pulse illumination, both PA signals and reflected US signals can be generated. Then, a linear array probe receives both PA and US signals, enabling simultaneous dual-modal PA and US imaging. Ex vivo experiments were conducted involving pencil lead, hair, and plastic tube with black spot, as well as in vivo experiment on human finger. The system's resolutions for PA and US imaging are 215 um and 91.125 um, with signal-to-noise ratios for PA and US signals reached up to 37.48 dB and 29.75 dB, respectively, proving the feasibility of the coPAUS dual-modal imaging. The proposed coPAUS system with disposable opto-acoustic window provides an immediate and cost-effective approach to enable US imaging capability based on an existing PA imaging system.
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