麻风树（Jatropha maheshwari）乙醇提取物的体外药理学评价
Invitro Pharmacological Evaluations Of Ethanolic Extract Of Jatropha Maheshwari
AI总结：
该研究评估了麻风树乙醇提取物的体外药理活性，发现其具有强抗氧化、伤口愈合、抗溃疡和抗炎作用，为开发天然药物提供了依据。
摘要：
目的：评估麻风树（Jatropha maheshwari）的抗氧化、伤口愈合、抗溃疡和抗炎特性。方法：从坎亚库马里区采集麻风树并鉴定。使用乙醇进行连续热渗滤提取。通过DPPH和ABTS试验评估抗氧化活性。使用3T3-L1小鼠成纤维细胞系进行伤口划痕试验评估伤口愈合潜力。通过酸中和能力（ANC）和H+/K+-ATP酶抑制活性方法测量抗溃疡活性。通过乙醇提取物的剂量依赖性研究确定抗炎作用。结果：抗氧化活性：粗提物表现出强抗氧化能力，DPPH和ABTS的抑制百分比分别为88%和75.7%。伤口愈合活性：处理过的3T3-L1细胞系中的伤口闭合率达到97.88%，表明具有强效伤口愈合特性。抗溃疡活性：与奥美拉唑一起测试时，提取物与对照相比显示出80.1%的抑制。每克抗酸剂的ANC在口服剂量10和500 μg/ml时分别记录为20和26。抗炎活性：相对于炎症对照，观察到剂量依赖性抑制百分比为30.1%（10 μg/ml）和96.5%（500 μg/ml）（p<0.001）。另外26.3%（10 μg/ml）和42.6%（500 μg/ml）的百分比进一步证实了抗炎活性。结论：麻风树显示出显著的抗氧化、伤口愈合、抗溃疡和抗炎特性。需要进一步研究以阐明这些药理作用背后的机制。
英文摘要：
Objective: To assess the antioxidant, wound healing, anti-ulcer, and anti-inflammatory properties of Jatropha maheshwari. Methods: Jatropha maheshwari was collected from Kanyakumari district and authenticated. Ethanol was used for continuous hot percolation extraction of the plant. Antioxidant activity was evaluated using DPPH and ABTS assays. The wound healing potential was assessed through a wound scratch assay using 3T3-L1 murine fibroblast cell lines. Anti-ulcer activity was measured using the acid-neutralizing capacity (ANC) and H+/K+-ATPase inhibitory activity methods. Anti-inflammatory effects were determined through dose-dependent studies of the ethanol extract. Results: Antioxidant Activity: The crude extract exhibited strong antioxidant capacity with percentage inhibition values of 88% (DPPH) and 75.7% (ABTS). Wound Healing Activity: The wound closure rate in treated 3T3-L1 cell lines reached 97.88%, indicating potent wound healing properties. Anti-Ulcer Activity: The extract demonstrated an 80.1% inhibition compared to the control when tested alongside omeprazole. ANC per gram of antacid was recorded at 20 and 26 for oral doses of 10 and 500 μg/ml, respectively. Anti-Inflammatory Activity: Dose-dependent inhibition percentages of 30.1% (10 μg/ml) and 96.5% (500 μg/ml) were observed (p<0.001) relative to inflammation control. Additional percentages of 26.3% (10 μg/ml) and 42.6% (500 μg/ml) further confirmed the anti-inflammatory activity. Conclusion: Jatropha maheshwari demonstrates significant antioxidant, wound healing, anti-ulcer, and anti-inflammatory properties. Further research is warranted to elucidate the mechanisms underlying these pharmacological effects.
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