基于介孔二氧化硅纳米粒子的智能纳米载体在结直肠癌治疗中的靶向药物递送
Mesoporous Silica Nanoparticles-based Smart Nanocarriers for Targeted Drug Delivery in Colorectal Cancer Therapy
AI总结：
本文综述了三种基于介孔二氧化硅纳米粒子的智能药物递送系统，通过独特功能化策略实现结直肠癌的靶向治疗，为克服常规化疗局限提供了新途径。
摘要：
结直肠癌（CRC）仍是全球癌症相关死亡的主要原因之一，凸显了对先进治疗策略的迫切需求。基于纳米粒子的药物递送系统已成为提高抗癌治疗特异性和疗效的有前景的方法。本综述考察了三种前沿的基于介孔二氧化硅纳米粒子（MSN）的药物递送系统以介绍新型CRC疗法，每种系统都利用独特的功能化策略实现靶向药物释放。第一种系统是透明质酸酶响应的MSN-HA/DOX，采用生物素修饰的透明质酸促进肿瘤微环境中的双重刺激药物释放，表现出增强的体内肿瘤抑制作用。DOX/SLN-PEG-Biotin利用聚乙二醇和生物素提高药物稳定性并靶向生物素过表达的CRC细胞，在体外和体内均展现出卓越的抗癌疗效。最后，半乳糖基化壳聚糖功能化的MSN通过去唾液酸糖蛋白受体实现靶向递送，提供可控的药物释放和强大的治疗潜力。总而言之，这些系统突显了CRC治疗中纳米粒子功能化的进展，为克服常规化疗的局限性提供了途径。需要进一步研究将这些创新转化为临床实践，确保安全性和可扩展性。
英文摘要：
Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, highlighting the urgent need for advanced therapeutic strategies. Nanoparticle-based drug delivery systems have emerged as a promising approach to improve the specificity and efficacy of anticancer treatments. This review examines three cutting-edge mesoporous silica nanoparticle (MSN)-based drug delivery to introduce novel CRC therapy, each utilizing unique functionalization strategies for targeted drug release. The first system, hyaluronidase-responsive MSN-HA/DOX, employs biotin-modified hyaluronic acid to facilitate dual-stimulus drug release in the tumor microenvironment, exhibiting enhanced in vivo tumor inhibition. The DOX/SLN-PEG-Biotin utilizes polyethylene glycol and biotin to improve drug stability and target biotin-overexpressing CRC cells, demonstrating superior anti-cancer efficacy in vitro and in vivo. Lastly, galactosylated chitosan-functionalized MSNs enable targeted delivery through asialoglycoprotein receptors, providing controlled drug release and strong therapeutic potential. Collectively, these systems highlight the advancements in nanoparticle functionalization for CRC treatment, offering a pathway to overcome the limitations of conventional chemotherapy. Further research is required to translate these innovations into clinical practice, ensuring safety and scalability.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
