机械敏感离子通道：古老而新颖

AI总结：

本文从纳米尺度热力学角度研究机械敏感离子通道，为膜片钳轨迹定义功与热，并揭示其信息处理能力、能量景观与进化之间的耦合。

摘要：

离子通道协调细胞与其环境之间的通信。这些是特殊的蛋白质，能够响应膜张力等刺激而改变形状，使离子穿过膜。由于这些“信件”以离子电流的形式书写和交换，这种通信的能量成本引起了许多人的兴趣。为此，我们介绍机械敏感离子通道的纳米尺度热力学，这相当于为膜片钳实验期间获得的轨迹定义功和热。我们还通过展示信息处理能力如何与通道的能量景观相耦合，讨论离子通道物理学与进化之间的相互作用。

英文摘要：

Ion channels orchestrate the communication between cells and their environment. These are special proteins capable of changing their shape to allow ions to pass through membranes in response to stimuli like membrane tension. As the letters are written and exchanged in the form of ionic currents, the energetic cost of this communication is of interest to many. To this end, we introduce the nanoscale thermodynamics of mechanosensitive ion channels, which amounts to defining work and heat for traces obtained during patch-clamp experiments. We also discuss the interplay between ion channel physics and evolution by showing how information-processing capabilities are coupled with the energy landscapes of channels.

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