揭示簇转移诱导的碎裂对强子治疗中$^{12}$C碎裂的影响
Unraveling the Effects of Cluster Transfer-Induced Breakups on $^{12}$C Fragmentation in Hadron Therapy
AI总结：
针对标准Geant4物理列表无法准确解释碳离子碎裂系统规律的问题，研究整合基于fresco CDCC-CRC建模的碎裂分量，复现了α粒子产生截面，并将新过程纳入框架以提升强子治疗剂量计算的准确性。
摘要：
通过与Divay等人及Dudouet等人报道的实验截面进行对比分析，本研究评估了标准Geant4 PhysicsLists（物理列表）处理$^{12}$C$-^{12}$C碎裂的能力。结果显示标准物理列表不足以解释碎裂的系统规律。为解决这一局限，本研究将碎裂的碎裂分量系统整合进标准物理列表中，成功复现了$α$粒子产生的微分截面和双微分截面。该碎裂分量采用fresco CDCC-CRC计算建模。随后这一全新物理过程被纳入Geant4框架，可用于计算水和组织中的剂量分布。应用该方法后，研究精确复现了布拉格峰区域的沉积剂量，与Liedner等人的实验数据相符，同时提升了剂量拖尾的准确可见度。
英文摘要：
The capability of standard Geant4 PhysicsLists to address the fragmentation of $^{12}$C$-^{12}$C was assessed through a comparative analysis with experimental cross sections reported by Divay et al. and Dudouet et al. The standard PhysicsLists were found to be inadequate in explaining the fragmentation systematics. To address this limitation, the breakup component of fragmentation was systematically integrated into the standard PhysicsList, which successfully replicated the differential and double differential cross sections for $α$ production. This breakup component was modeled using fresco CDCC-CRC calculations. This novel physics process was then incorporated into the Geant4 framework, facilitating the calculation of dose distributions in water and tissue. The application of this method demonstrated a precise reproduction of the dose deposited at the Bragg peak region, corroborating the experimental data from Liedner et al., thereby enhancing the accurate visibility of dose tailing.
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