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arXiv 2409.02065q-bio.NC

灵长类内侧背核与运动丘脑核团与皮层的解剖连接

Anatomical Connections of Primate Mediodorsal and Motor Thalamic Nuclei with the Cortex

Bianca Sieveritz, Roozbeh Kiani

AI总结:

本文系统综述了灵长类内侧背侧丘脑(MD)、腹前侧(VA)和腹外侧(VL)核团与皮层的解剖连接,揭示其连接复杂性远超传统认知,为丘脑功能建模和后续研究提供资源。

摘要:

非感觉性丘脑核团通过丘脑皮层和皮层-基底节-丘脑皮层环路与皮层相互作用。内侧背侧丘脑(MD)与前额叶皮层之间的交互连接在认知中尤为重要,而腹内侧(VM)、腹前侧(VA)和腹外侧(VL)丘脑与前额叶和运动皮层的交互连接则是感觉运动信息处理所必需的。然而,目前对灵长类MD、VA和VL核团连接性的理解有限且往往过于简化,这阻碍了能够解释它们在认知和感觉运动功能中贡献的精确模型的发展。当前的主流观点认为,MD与前额叶皮层相连,而VA和VL主要与前运动皮层和运动皮层相连。然而,过去的研究也报道了多种多样的连接,使这些核团能够整合来自多个脑系统的信息。在这篇综述中,我们全面概述了灵长类MD、VA和VL与皮层的解剖连接性。通过综合近期发现,我们旨在为学生、该领域的新进入者以及正在发展丘脑功能新理论或模型的专家提供有价值的资源。我们的综述强调了这些连接的复杂性,并强调需要进一步研究以充分理解这些丘脑核团在灵长类中的多样作用。

英文摘要:

Non-sensory thalamic nuclei interact with the cortex through thalamocortical and cortico-basal ganglia-thalamocortical loops. Reciprocal connections between the mediodorsal thalamus (MD) and the prefrontal cortex are particularly important in cognition, while the reciprocal connections of the ventromedial (VM), ventral anterior (VA), and ventrolateral (VL) thalamus with the prefrontal and motor cortex are necessary for sensorimotor information processing. However, limited and often oversimplified understanding of the connectivity of the MD, VA, and VL nuclei in primates have hampered development of accurate models that explain their contribution to cognitive and sensorimotor functions. The current prevalent view suggests that the MD connects with the prefrontal cortex, while the VA and VL primarily connect with the premotor and motor cortices. However, past studies have also reported diverse connections that enable these nuclei to integrate information across a multitude of brain systems. In this review, we provide a comprehensive overview of the anatomical connectivity of the primate MD, VA, and VL with the cortex. By synthesizing recent findings, we aim to offer a valuable resource for students, newcomers to the field, and experts developing new theories or models of thalamic function. Our review highlights the complexity of these connections and underscores the need for further research to fully understand the diverse roles of these thalamic nuclei in primates.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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