2023年意大利伦巴第大区登革热疫情：One-Health视角
The 2023 Dengue Outbreak in Lombardy, Italy: A One-Health Perspective
AI总结：
本文从One-Health视角报告了2023年意大利伦巴第大区一起DENV-1本土登革热疫情，结合血清学筛查、昆虫学调查和建模分析，估计R0为1.31、代际时间18.3天，并强调多部门协同监测对控制虫媒病毒传播的重要性。
摘要：
引言：本文报告了2023年夏季在意大利北部伦巴第大区一个小村庄发生的大规模本土登革热（DENV）疫情的病毒学、昆虫学和流行病学特征。方法：在2023年8月18日诊断出首例本土病例后，实施了公共卫生措施，包括流行病学调查和病媒控制措施。向居民提供了DENV抗体检测的血清学筛查。对于DENV IgM阳性者，采集第二份样本以检测DENV RNA并验证血清转化。同时开展了昆虫学和流行病学调查。通过建模分析估计登革热的代际时间、传播潜力、传播距离，并评估诊断延迟。结果：共有416名受试者参与了筛查项目，其中20人被确定为DENV-1病例（15例确诊，5例疑似）。此外，24名因提示性症状就诊于当地急诊科的有症状受试者被诊断为DENV-1感染，另有1例通过献血筛查发现。估计平均代际时间为18.3天（95%置信区间：13.1-23.5天）。估计R0为1.31（95%置信区间：0.76-1.98）；90%的传播发生在500米范围内。对46组蚊虫样本进行的昆虫学调查显示，仅有一组DENV-1检测呈阳性。讨论：本报告强调了协同监测的重要性，包括病毒学、昆虫学和公共卫生措施，以控制虫媒病毒感染的传播。
英文摘要：
Introduction. Here we reported the virological, entomological and epidemiological characteristics of the large autochthonous outbreak of dengue (DENV) occurred in a small village of the Lombardy region (Northern Italy) during summer 2023. Methods. After the diagnosis of the first autochthonous case on 18 August 2023, public health measures, including epidemiological investigation and vector control measures, were carried out. A serological screening for DENV antibodies detection was offered to the population. In the case of positive DENV IgM, a second sample was collected to detect DENV RNA and verify seroconversion. Entomological and epidemiological investigations were also performed. A modeling analysis was conducted to estimate the dengue generation time, transmission potential, distance of transmission, and assess diagnostic delays. Results. Overall, 416 subjects participated to the screening program and 20 were identified as DENV-1 cases (15 confirmed and 5 probable). In addition, DENV-1 infection was diagnosed in 24 symptomatic subjects referred to the local Emergency Room Department for suggestive symptoms and 1 case was identified through blood donation screening. The average generation time was estimated to be 18.3 days (95% CI: 13.1-23.5 days). R0 was estimated at 1.31 (95% CI: 0.76-1.98); 90% of transmission occurred within 500m. Entomological investigations performed in 46 pools of mosquitoes revealed the presence of only one positive pool for DENV-1. Discussion. This report highlights the importance of synergic surveillance, including virological, entomological and public health measures to control the spread of arboviral infections.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
