用于骨组织工程的、由毛细管悬浮液制备的具有互连孔隙的层级材料
Hierarchical materials with interconnected pores from capillary suspensions for bone tissue engineering
AI总结：
本文将毛细管悬浮液与冷冻浇注结合，制备孔径跨尺度、开放且高孔隙率的氧化铝和β-TCP层级多孔支架，并通过流变分析揭示次级流体与固相亲和性的影响。
摘要：
人口老龄化导致对骨移植物的需求不断增长，这为制造多孔陶瓷以辅助骨重建带来了新机遇。在本研究中，我们考察了一种以简便且可调方式制造层级多孔结构的新颖且有前景的方法。该方法将毛细管悬浮液这一新技术与冷冻浇注相结合；毛细管悬浮液通过混合固体颗粒和两种不混溶液体形成，其中一种液体的体积分数低于5 vol%。我们已成功制得氧化铝和β-TCP材料，其最小和最大孔径分别为<2 μm和20–50 μm。显微结构呈现完全开放的孔隙，且孔隙率较高（>60%）。毛细管悬浮液的流变行为表明，对于氧化铝体系，二氧化硅纳米悬浮液作为次级流体会比蔗糖形成更强的内部颗粒网络。相反，在β-TCP体系中观察到相反结果。这些差异归因于次级流体与固体装载量之间亲和性的变化。我们对两种体系的研究深化了关于毛细管悬浮液这一新领域的认识，并证明了其在用于骨组织工程的层级多孔支架中的应用。
英文摘要：
The increasing demand for bone grafts due to the aging population has opened new opportunities for the manufacture of porous ceramics to assist in bone reconstruction. In our study, we investigate a new, promising method to manufacture hierarchically porous structures in a straightforward, and tuneable way. It consists of combining the novel technology of capillary suspensions, formed by mixing solid particles and two immiscible liquids, one less than 5 vol%, with freeze casting. We have successfully achieved alumina and $β$-TCP materials with both <2 $μ$m and 20-50 $μ$m as the smallest and largest pore size, respectively. The microstructure exhibits fully open pores and high levels of porosity (>60%). The capillary suspensions' rheological behaviour indicates that silica nano-suspensions as a secondary fluid creates a stronger internal particle network than sucrose for the alumina system. Conversely, the opposite was observed with the $β$-TCP system. These differences were attributed to the change in affinity between the secondary fluids and the solid loading. Our study, both systems has served to deepen the knowledge about the new area of capillary suspensions and proves their use in hierarchical porous scaffolds for bone tissue engineering.
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