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arXiv 2408.01431cs.CYcs.AI
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构建用于基础模型转化与临床整合的伦理可信生物医学AI生态系统

Building an Ethical and Trustworthy Biomedical AI Ecosystem for the Translational and Clinical Integration of Foundational Models

University of California, Los Angeles(加州大学洛杉矶分校);European Molecular Biology Laboratory - European Bioinformatics Institute (EMBL-EBI)(欧洲分子生物学实验室-欧洲生物信息研究所(EMBL-EBI))

Simha Sankar Baradwaj, Destiny Gilliland, Jack Rincon, Henning Hermjakob, Yu Yan, Irsyad Adam, Gwyneth Lemaster, Dean Wang, Karol Watson, Alex Bui, Wei Wang, Peipei Ping

AI总结:

该综述聚焦基础模型在生物医学AI领域的应用,分析构建伦理可信生态系统的挑战,提出全流程应对策略及管理、共同设计原则,推动模型负责任地转化到临床场景,助力打造公平可信的生物医学AI生态。

摘要:

基础模型(Foundational Models, FMs)因其能够表征多模态生物医学数据并赋予其上下文关联的能力,在生物医学AI生态系统中受到越来越多的关注。这些能力使FMs成为可用于多种任务的宝贵工具,包括生物医学推理、假设生成以及复杂成像数据解读。在本综述论文中,我们探讨了构建伦理可信的生物医学AI生态系统所面临的独特挑战,重点关注FMs的开发及其下游应用。我们探索了可在整个生物医学AI流程中实施的策略,以有效应对这些挑战,确保这些FMs以负责任的方式转化到临床和转化研究场景中。此外,我们强调了关键管理和共同设计原则的重要性,这些原则不仅能确保稳健的监管,还能保证所有利益相关者的利益,尤其是参与或受这些临床和转化应用影响的群体的利益得到充分代表。我们旨在赋能生物医学AI社区,使其负责任且有效地利用这些模型。在我们探索这一令人兴奋的前沿领域时,我们对伦理管理、共同设计和负责任转化的集体承诺,将有助于确保FMs的发展切实提升患者护理和医疗决策水平,最终构建一个更公平、更可信的生物医学AI生态系统。

英文摘要:

Foundational Models (FMs) are gaining increasing attention in the biomedical AI ecosystem due to their ability to represent and contextualize multimodal biomedical data. These capabilities make FMs a valuable tool for a variety of tasks, including biomedical reasoning, hypothesis generation, and interpreting complex imaging data. In this review paper, we address the unique challenges associated with establishing an ethical and trustworthy biomedical AI ecosystem, with a particular focus on the development of FMs and their downstream applications. We explore strategies that can be implemented throughout the biomedical AI pipeline to effectively tackle these challenges, ensuring that these FMs are translated responsibly into clinical and translational settings. Additionally, we emphasize the importance of key stewardship and co-design principles that not only ensure robust regulation but also guarantee that the interests of all stakeholders, especially those involved in or affected by these clinical and translational applications are adequately represented. We aim to empower the biomedical AI community to harness these models responsibly and effectively. As we navigate this exciting frontier, our collective commitment to ethical stewardship, co-design, and responsible translation will be instrumental in ensuring that the evolution of FMs truly enhances patient care and medical decision making, ultimately leading to a more equitable and trustworthy biomedical AI ecosystem.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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