3T下3D无失真、减视场扩散制备GRE序列
3D distortion-free, reduced field of view diffusion-prepared GRE at 3T
AI总结：
本研究开发了3T下3D无失真减视场扩散制备GRE序列，经体模和5名健康志愿者脊髓成像验证，该序列与标准DW-SS-EPI相比ADC估计一致，且图像质量更优、失真更少，可实现无失真3D扩散制备成像。
摘要：
目的：开发一种3D无失真减视场（reduced-FOV）扩散制备GRE（梯度回波）序列，并验证其在健康志愿者脊髓扩散成像中的在体应用价值。方法：通过在扩散制备的相位编码方向施加选层倾倒脉冲，结合幅度稳定器，实现3D多激发减视场扩散制备GRE（RFOV-DP-GRE）采集。在体模实验中评估所开发减视场方法的效能及ADC（表观扩散系数）估计的准确性。此外，招募5名健康志愿者，在3T场强下分别采用所提出的序列和标准自旋回波扩散加权单次激发EPI（回波平面成像）序列（DW-SS-EPI）进行脊髓成像。由两名资深阅片者评估图像质量、主观SNR（信噪比）及图像失真情况，并对表观SNR进行定量测量。结果：体模扫描验证了所提出减视场方法的效能。与DW-SS-EPI相比，RFOV-DP-GRE测得的ADC估计值具有一致性。在体实验中，与DW-SS-EPI相比，RFOV-DP-GRE在保持主观SNR的同时，图像质量更优，主观感知到的失真更少。结论：采用所提出的序列可实现3D无失真扩散制备成像。
英文摘要：
Purpose: To develop a 3D distortion-free reduced-FOV diffusion-prepared GRE sequence and demonstrate its in-vivo application for diffusion imaging of the spinal cord in healthy volunteers. Methods: A 3D multi-shot reduced-FOV diffusion-prepared GRE (RFOV-DP-GRE) acquisition is achieved using a slice-selective tip-down pulse in the phase encoding direction in the diffusion preparation, combined with magnitude stabilisers. The efficacy of the developed reduced FOV approach and accuracy of ADC estimates were evaluated in a phantom. In addition, 5 healthy volunteers were enrolled and scanned at 3T using the proposed sequence and a standard spin echo diffusion-weighted single-shot EPI sequence (DW-SS-EPI) for spinal cord imaging. Image quality, perceived SNR and image distortion were assessed by two expert readers and quantitative measurements of apparent SNR were performed. Results: The phantom scan demonstrates the efficacy of the proposed reduced FOV approach. Consistent ADC estimates were measured with RFOV-DP-GRE when compared with DW-SS-EPI. In-vivo, RFOV-DP-GRE demonstrated improved image quality and reduced perceived distortion, while maintaining perceived SNR compared to DW-SS-EPI. Conclusion: 3D Distortion-free diffusion-prepared imaging can be achieved using the proposed sequence
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
